Lih-Yun. Hsu, et.al., A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity., The Journal of experimental medicine, 2009, 206

http://rdf.ncbi.nlm.nih.gov/pubmed/19841086

Lih-Yun. Hsu, et.al., A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity., The Journal of experimental medicine, 2009, 206

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Zap70<tm2.1Weis>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4399123

class

http://purl.org/net/cito/citesAsAuthority

• Zap70<tm2.1Weis>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4399123

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal T cell clonal deletion_Zap70<m1Saka>/Zap70<m1Saka>
  http://metadb.riken.jp/0005002IBALBcZap70m1SakaZap70m1SakaZap70m1Saka
• abnormal splenic cell ratio_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0008826C129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• decreased susceptibility to induced arthritis_Zap70<m1Saka>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0003436I129S4SvJaeBALBcZap70m1SakaZap70tm21WeisZap70m1SakaZap70tm21Weis
• decreased CD8-positive, alpha-beta T cell number_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0008079B6129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• abnormal positive T cell selection_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
  http://metadb.riken.jp/0004919I129S4SvJaeC57BL6JDBA2JZap70tm21WeisZap70tm21WeisTgTcraHYTcrbHY71VboZap70tm21WeisTgTcraHYTcrbHY71Vbo
• decreased CD4-positive, alpha beta T cell number_Zap70<m1Saka>/Zap70<m1Saka>
  http://metadb.riken.jp/0008075IBALBcZap70m1SakaZap70m1SakaZap70m1Saka
• abnormal positive T cell selection_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0004919C129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• abnormal thymocyte activation_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0003850C129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• increased memory T cell number_Zap70<m1Saka>/Zap70<m1Saka>
  http://metadb.riken.jp/0008049IBALBcZap70m1SakaZap70m1SakaZap70m1Saka
• abnormal thymus cell ratio_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0008827C129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• decreased interleukin-2 secretion_Zap70<m1Saka>/Zap70<m1Saka>
  http://metadb.riken.jp/0008688IBALBcZap70m1SakaZap70m1SakaZap70m1Saka
• abnormal positive T cell selection_Zap70<m1Saka>/Zap70<m1Saka>
  http://metadb.riken.jp/0004919IBALBcZap70m1SakaZap70m1SakaZap70m1Saka
• decreased CD8-positive, alpha-beta T cell number_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0008079C129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• decreased T cell proliferation_Zap70<m1Saka>/Zap70<m1Saka>
  http://metadb.riken.jp/0005095IBALBcZap70m1SakaZap70m1SakaZap70m1Saka
• abnormal thymus cell ratio_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0008827B6129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• increased activated T cell number_Zap70<m1Saka>/Zap70<m1Saka>
  http://metadb.riken.jp/0001829IBALBcZap70m1SakaZap70m1SakaZap70m1Saka
• decreased interleukin-2 secretion_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0008688C129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• abnormal positive T cell selection_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>,Tg(DO11.10)10Dlo/?
  http://metadb.riken.jp/0004919I129S4SvJaeBALBcZap70tm21WeisZap70tm21WeisTgDO111010DloTgDO111010DloZap70tm21Weis
• abnormal T cell clonal deletion_Zap70<m1Saka>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0005002I129S4SvJaeBALBcZap70m1SakaZap70tm21WeisZap70m1SakaZap70tm21Weis
• increased activated T cell number_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0001829C129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• abnormal splenic cell ratio_Zap70<m1Saka>/Zap70<m1Saka>
  http://metadb.riken.jp/0008826IBALBcZap70m1SakaZap70m1SakaZap70m1Saka
• increased interleukin-17 secretion_Zap70<m1Saka>/Zap70<m1Saka>
  http://metadb.riken.jp/0008681IBALBcZap70m1SakaZap70m1SakaZap70m1Saka
• decreased regulatory T cell number_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0004974C129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• abnormal thymus cell ratio_Zap70<m1Saka>/Zap70<m1Saka>
  http://metadb.riken.jp/0008827IBALBcZap70m1SakaZap70m1SakaZap70m1Saka
• decreased CD4-positive, alpha beta T cell number_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0008075C129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• abnormal T cell clonal deletion_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>,Tg(TcraH-Y,TcrbH-Y)71Vbo/?
  http://metadb.riken.jp/0005002I129S4SvJaeC57BL6JDBA2JZap70tm21WeisZap70tm21WeisTgTcraHYTcrbHY71VboZap70tm21WeisTgTcraHYTcrbHY71Vbo
• abnormal lymph node cell ratio_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0008828C129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• increased interleukin-17 secretion_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0008681C129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• decreased T cell proliferation_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0005095C129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• decreased CD8-positive, alpha-beta T cell number_Zap70<m1Saka>/Zap70<m1Saka>
  http://metadb.riken.jp/0008079IBALBcZap70m1SakaZap70m1SakaZap70m1Saka
• abnormal CD8-positive, alpha-beta T cell differentiation_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0008080B6129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• abnormal thymocyte activation_Zap70<m1Saka>/Zap70<m1Saka>
  http://metadb.riken.jp/0003850IBALBcZap70m1SakaZap70m1SakaZap70m1Saka
• abnormal regulatory T cell physiology_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0004946C129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• abnormal T cell clonal deletion_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0005002C129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• abnormal lymph node cell ratio_Zap70<m1Saka>/Zap70<m1Saka>
  http://metadb.riken.jp/0008828IBALBcZap70m1SakaZap70m1SakaZap70m1Saka
• decreased regulatory T cell number_Zap70<m1Saka>/Zap70<m1Saka>
  http://metadb.riken.jp/0004974IBALBcZap70m1SakaZap70m1SakaZap70m1Saka
• increased memory T cell number_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0008049C129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis
• increased susceptibility to induced arthritis_Zap70<m1Saka>/Zap70<m1Saka>
  http://metadb.riken.jp/0003724IBALBcZap70m1SakaZap70m1SakaZap70m1Saka
• decreased CD4-positive, alpha beta T cell number_Zap70<tm2.1Weis>/Zap70<tm2.1Weis>
  http://metadb.riken.jp/0008075B6129S4Zap70tm21WeisZap70tm21WeisZap70tm21WeisZap70tm21Weis