abnormal positive T cell selection_Ppp3r1<tm2Grc>/Ppp3r1<tm2.1Grc>,Tg(Lck-cre)1Cwi/0

http://metadb.riken.jp/0004919I129S6SvEvTacC57BL6DBA2Ppp3r1tm2GrcPpp3r1tm21GrcTgLckcre1Cwi0Ppp3r1tm2GrcTgLckcre1CwiPpp3r1tm21Grc

abnormal positive T cell selection_Ppp3r1<tm2Grc>/Ppp3r1<tm2.1Grc>,Tg(Lck-cre)1Cwi/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Christopher B Wilson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448687
• protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
  http://metadb.riken.jp/db/mgi_rdf/MGI:107172

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ppp3r1<tm2Grc>/Ppp3r1<tm2.1Grc>,Tg(Lck-cre)1Cwi/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ppp3r1<tm2Grc>|Tg(Lck-cre)1Cwi|Ppp3r1<tm2.1Grc>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal positive T cell selection
  http://purl.obolibrary.org/obo/MP_0004919

文献

http://purl.org/net/cito/citesAsAuthority

• Joel R. Neilson, et.al., Calcineurin B1 is essential for positive but not negative selection during thymocyte development., Immunity, 2004, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/15030770