abnormal B cell negative selection_Cd22<tm1Eac>/Cd22<+>,Lyn<tm1Ard>/Lyn<+>,Ptpn6<me-v>/Ptpn6<+>,Tg(IghelMD4)4Ccg/0

http://metadb.riken.jp/0004944I129P2OlaHsdC57BL6Cd22tm1EacCd22Lyntm1ArdLynPtpn6mevPtpn6TgIghelMD44Ccg0LynCd22Cd22tm1EacPtpn6TgIghelMD44CcgPtpn6mevLyntm1Ard

abnormal B cell negative selection_Cd22<tm1Eac>/Cd22<+>,Lyn<tm1Ard>/Lyn<+>,Ptpn6<me-v>/Ptpn6<+>,Tg(IghelMD4)4Ccg/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 4, Christopher C Goodnow
  http://metadb.riken.jp/db/mgi_rdf/MGI:3053738
• protein tyrosine phosphatase, non-receptor type 6
  http://metadb.riken.jp/db/mgi_rdf/MGI:96055
• LYN proto-oncogene, Src family tyrosine kinase
  http://metadb.riken.jp/db/mgi_rdf/MGI:96892
• CD22 antigen
  http://metadb.riken.jp/db/mgi_rdf/MGI:88322

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cd22<tm1Eac>/Cd22<+>,Lyn<tm1Ard>/Lyn<+>,Ptpn6<me-v>/Ptpn6<+>,Tg(IghelMD4)4Ccg/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lyn<+>|Cd22<+>|Cd22<tm1Eac>|Ptpn6<+>|Tg(IghelMD4)4Ccg|Ptpn6<me-v>|Lyn<tm1Ard>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal B cell negative selection
  http://purl.obolibrary.org/obo/MP_0004944

文献

http://purl.org/net/cito/citesAsAuthority

• R J. Cornall, et.al., Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection., Immunity, 1998, 8
  http://rdf.ncbi.nlm.nih.gov/pubmed/9586639