R J. Cornall, et.al., Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection., Immunity, 1998, 8

http://rdf.ncbi.nlm.nih.gov/pubmed/9586639

R J. Cornall, et.al., Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection., Immunity, 1998, 8

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal B cell negative selection_Cd22<tm1Eac>/Cd22<+>,Lyn<tm1Ard>/Lyn<+>,Ptpn6<me-v>/Ptpn6<+>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0004944I129P2OlaHsdC57BL6Cd22tm1EacCd22Lyntm1ArdLynPtpn6mevPtpn6TgIghelMD44Ccg0LynCd22Cd22tm1EacPtpn6TgIghelMD44CcgPtpn6mevLyntm1Ard
• abnormal mature B cell morphology_Cd22<tm1Eac>/Cd22<+>,Lyn<tm1Ard>/Lyn<+>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008171I129P2OlaHsdC57BL6Cd22tm1EacCd22Lyntm1ArdLynTgIghelMD44Ccg0Cd22Cd22tm1EacLynLyntm1ArdTgIghelMD44Ccg
• abnormal mature B cell morphology_Cd22<tm1Eac>/Cd22<+>,Lyn<tm1Ard>/Lyn<+>,Ptpn6<me-v>/Ptpn6<+>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008171I129P2OlaHsdC57BL6Cd22tm1EacCd22Lyntm1ArdLynPtpn6mevPtpn6TgIghelMD44Ccg0LynCd22Cd22tm1EacPtpn6TgIghelMD44CcgPtpn6mevLyntm1Ard
• abnormal mature B cell morphology_Cd22<tm1Eac>/Cd22<+>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008171I129P2OlaHsdC57BL6Cd22tm1EacCd22TgIghelMD44Ccg0Cd22tm1EacCd22TgIghelMD44Ccg
• increased IgM level_Cd22<tm1Eac>/Cd22<+>,Lyn<tm1Ard>/Lyn<+>,Ptpn6<me-v>/Ptpn6<+>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0002494I129P2OlaHsdC57BL6Cd22tm1EacCd22Lyntm1ArdLynPtpn6mevPtpn6TgIghelMD44Ccg0LynCd22Cd22tm1EacPtpn6TgIghelMD44CcgPtpn6mevLyntm1Ard
• abnormal mature B cell morphology_Lyn<tm1Ard>/Lyn<+>,Ptpn6<me-v>/Ptpn6<+>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008171I129P2OlaHsdC57BL6Lyntm1ArdLynPtpn6mevPtpn6TgIghelMD44Ccg0LynPtpn6mevPtpn6TgIghelMD44CcgLyntm1Ard
• abnormal mature B cell morphology_Lyn<tm1Ard>/Lyn<tm1Ard>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008171I129P2OlaHsdC57BL6Lyntm1ArdLyntm1ArdTgIghelMD44Ccg0Lyntm1ArdTgIghelMD44Ccg
• abnormal mature B cell morphology_Lyn<tm1Ard>/Lyn<+>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008171I129P2OlaHsdC57BL6Lyntm1ArdLynTgIghelMD44Ccg0LynTgIghelMD44CcgLyntm1Ard
• abnormal mature B cell morphology_Cd22<tm1Eac>/Cd22<+>,Ptpn6<me-v>/Ptpn6<+>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008171I129P2OlaHsdC57BL6Cd22tm1EacCd22Ptpn6mevPtpn6TgIghelMD44Ccg0Ptpn6TgIghelMD44CcgPtpn6mevCd22Cd22tm1Eac
• abnormal B cell negative selection_Cd22<tm1Eac>/Cd22<+>,Lyn<tm1Ard>/Lyn<+>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0004944I129P2OlaHsdC57BL6Cd22tm1EacCd22Lyntm1ArdLynTgIghelMD44Ccg0Cd22Cd22tm1EacLynLyntm1ArdTgIghelMD44Ccg
• abnormal B cell activation_Lyn<tm1Ard>/Lyn<tm1Ard>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008217I129P2OlaHsdC57BL6Lyntm1ArdLyntm1ArdTgIghelMD44Ccg0Lyntm1ArdTgIghelMD44Ccg
• abnormal mature B cell morphology_Ptpn6<me-v>/Ptpn6<+>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008171I129P2OlaHsdC57BL6Ptpn6mevPtpn6TgIghelMD44Ccg0TgIghelMD44CcgPtpn6Ptpn6mev
• absent B-1 B cells_Lyn<tm1Ard>/Lyn<tm1Ard>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0008202I129P2OlaHsdC57BL6Lyntm1ArdLyntm1ArdTgIghelMD44Ccg0Lyntm1ArdTgIghelMD44Ccg
• abnormal B cell negative selection_Cd22<tm1Eac>/Cd22<+>,Ptpn6<me-v>/Ptpn6<+>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0004944I129P2OlaHsdC57BL6Cd22tm1EacCd22Ptpn6mevPtpn6TgIghelMD44Ccg0Ptpn6TgIghelMD44CcgPtpn6mevCd22Cd22tm1Eac
• increased IgM level_Lyn<tm1Ard>/Lyn<tm1Ard>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0002494I129P2OlaHsdC57BL6Lyntm1ArdLyntm1ArdTgIghelMD44Ccg0Lyntm1ArdTgIghelMD44Ccg
• abnormal B cell negative selection_Lyn<tm1Ard>/Lyn<tm1Ard>,Tg(IghelMD4)4Ccg/0
  http://metadb.riken.jp/0004944I129P2OlaHsdC57BL6Lyntm1ArdLyntm1ArdTgIghelMD44Ccg0Lyntm1ArdTgIghelMD44Ccg