increased bone resorption_Gna11<tm1Soff>/Gna11<tm1Soff>,Gnaq<tm2Soff>/Gnaq<tm2Soff>,Tg(PTH-cre)4167Slib/0

http://metadb.riken.jp/0004992I129P2OlaHsd129S7SvEvBrdC57BL6Gna11tm1SoffGna11tm1SoffGnaqtm2SoffGnaqtm2SoffTgPTHcre4167Slib0TgPTHcre4167SlibGna11tm1SoffGnaqtm2Soff

increased bone resorption_Gna11<tm1Soff>/Gna11<tm1Soff>,Gnaq<tm2Soff>/Gnaq<tm2Soff>,Tg(PTH-cre)4167Slib/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• guanine nucleotide binding protein, alpha q polypeptide
  http://metadb.riken.jp/db/mgi_rdf/MGI:95776
• guanine nucleotide binding protein, alpha 11
  http://metadb.riken.jp/db/mgi_rdf/MGI:95766
• transgene insertion 4167, Steven K Libutti
  http://metadb.riken.jp/db/mgi_rdf/MGI:2683307

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gna11<tm1Soff>/Gna11<tm1Soff>,Gnaq<tm2Soff>/Gnaq<tm2Soff>,Tg(PTH-cre)4167Slib/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(PTH-cre)4167Slib|Gna11<tm1Soff>|Gnaq<tm2Soff>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased bone resorption
  http://purl.obolibrary.org/obo/MP_0004992

文献

http://purl.org/net/cito/citesAsAuthority

• Nina. Wettschureck, et.al., Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor., Molecular endocrinology (Baltimore, Md.), 2007, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/16988000