increased B cell number_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>,Igh-J<tm1Cgn>/Igh<tm4Cgn>,Tg(Cr2-cre)3Cgn/0

http://metadb.riken.jp/0005014I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26Sortm4IkbkbRskyIghJtm1CgnIghtm4CgnTgCr2cre3Cgn0TgCr2cre3CgnIghtm4CgnIghJtm1CgnGtROSA26Sortm4IkbkbRsky

increased B cell number_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>,Igh-J<tm1Cgn>/Igh<tm4Cgn>,Tg(Cr2-cre)3Cgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 3, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:3708319
• immunoglobulin heavy chain, joining region
  http://metadb.riken.jp/db/mgi_rdf/MGI:96461
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• immunoglobulin heavy chain complex
  http://metadb.riken.jp/db/mgi_rdf/MGI:96442

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>,Igh-J<tm1Cgn>/Igh<tm4Cgn>,Tg(Cr2-cre)3Cgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Cr2-cre)3Cgn|Igh<tm4Cgn>|Igh-J<tm1Cgn>|Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased B cell number
  http://purl.obolibrary.org/obo/MP_0005014

文献

http://purl.org/net/cito/citesAsAuthority

• Lakshmi. Srinivasan, et.al., PI3 kinase signals BCR-dependent mature B cell survival., Cell, 2009, 139
  http://rdf.ncbi.nlm.nih.gov/pubmed/19879843