Lakshmi. Srinivasan, et.al., PI3 kinase signals BCR-dependent mature B cell survival., Cell, 2009, 139

http://rdf.ncbi.nlm.nih.gov/pubmed/19879843

Lakshmi. Srinivasan, et.al., PI3 kinase signals BCR-dependent mature B cell survival., Cell, 2009, 139

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4430550
• Gt(ROSA)26Sor<tm7(Pik3ca*,EGFP)Rsky>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4430527
• Gt(ROSA)26Sor<tm9(Rac1*,EGFP)Rsky>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4430551

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased B cell number_Foxo1<tm1.1Rdp>/Foxo1<+>,Igh-J<tm1Cgn>/Igh<tm4Cgn>,Tg(Cr2-cre)3Cgn/0
  http://metadb.riken.jp/0005014I129P2OlaHsd129S1SvFoxo1tm11RdpFoxo1IghJtm1CgnIghtm4CgnTgCr2cre3Cgn0TgCr2cre3CgnFoxo1tm11RdpIghtm4CgnIghJtm1CgnFoxo1
• absent marginal zone B cells_Foxo1<tm1Rdp>/Foxo1<tm1.1Rdp>,Igh-J<tm1Cgn>/Igh<tm4Cgn>,Tg(Cr2-cre)3Cgn/0
  http://metadb.riken.jp/0008183I129P2OlaHsd129S1SvFoxo1tm1RdpFoxo1tm11RdpIghJtm1CgnIghtm4CgnTgCr2cre3Cgn0Foxo1tm1RdpIghJtm1CgnIghtm4CgnFoxo1tm11RdpTgCr2cre3Cgn
• decreased mature B cell number_Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>,Igh-J<tm1Cgn>/Igh<tm4Cgn>,Tg(Cr2-cre)3Cgn/0
  http://metadb.riken.jp/0008211I129P2OlaHsdC57BL6GtROSA26Sortm8Map2k1EGFPRskyGtROSA26Sortm8Map2k1EGFPRskyIghJtm1CgnIghtm4CgnTgCr2cre3Cgn0IghJtm1CgnIghtm4CgnTgCr2cre3CgnGtROSA26Sortm8Map2k1EGFPRsky
• decreased mature B cell number_Igh-J<tm1Cgn>/Igh<tm4Cgn>,Tg(Cr2-cre)3Cgn/0
  http://metadb.riken.jp/0008211I129P2OlaHsdIghJtm1CgnIghtm4CgnTgCr2cre3Cgn0IghJtm1CgnIghtm4CgnTgCr2cre3Cgn
• neonatal lethality, complete penetrance_Gt(ROSA)26Sor<tm7(Pik3ca*,EGFP)Rsky>/Gt(ROSA)26Sor<tm7(Pik3ca*,EGFP)Rsky>,Tg(Cr2-cre)3Cgn/0
  http://metadb.riken.jp/0011087IC57BL6GtROSA26Sortm7Pik3caEGFPRskyGtROSA26Sortm7Pik3caEGFPRskyTgCr2cre3Cgn0TgCr2cre3CgnGtROSA26Sortm7Pik3caEGFPRsky
• increased B cell number_Foxo1<tm1Rdp>/Foxo1<tm1.1Rdp>,Igh-J<tm1Cgn>/Igh<tm4Cgn>,Tg(Cr2-cre)3Cgn/0
  http://metadb.riken.jp/0005014I129P2OlaHsd129S1SvFoxo1tm1RdpFoxo1tm11RdpIghJtm1CgnIghtm4CgnTgCr2cre3Cgn0Foxo1tm1RdpIghJtm1CgnIghtm4CgnFoxo1tm11RdpTgCr2cre3Cgn
• preweaning lethality, complete penetrance_Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Cr2-cre)3Cgn/0
  http://metadb.riken.jp/0011100I129S4SvJaePtentm1HwuPtentm1HwuTgCr2cre3Cgn0TgCr2cre3CgnPtentm1Hwu
• increased B cell number_Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>/Gt(ROSA)26Sor<tm4(Ikbkb)Rsky>,Igh-J<tm1Cgn>/Igh<tm4Cgn>,Tg(Cr2-cre)3Cgn/0
  http://metadb.riken.jp/0005014I129P2OlaHsdC57BL6GtROSA26Sortm4IkbkbRskyGtROSA26Sortm4IkbkbRskyIghJtm1CgnIghtm4CgnTgCr2cre3Cgn0TgCr2cre3CgnIghtm4CgnIghJtm1CgnGtROSA26Sortm4IkbkbRsky
• decreased mature B cell number_Gt(ROSA)26Sor<tm9(Rac1*,EGFP)Rsky>/Gt(ROSA)26Sor<tm9(Rac1*,EGFP)Rsky>,Igh-J<tm1Cgn>/Igh<tm4Cgn>,Tg(Cr2-cre)3Cgn/0
  http://metadb.riken.jp/0008211I129P2OlaHsdC57BL6GtROSA26Sortm9Rac1EGFPRskyGtROSA26Sortm9Rac1EGFPRskyIghJtm1CgnIghtm4CgnTgCr2cre3Cgn0IghJtm1CgnIghtm4CgnGtROSA26Sortm9Rac1EGFPRskyTgCr2cre3Cgn

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4430550
• Gt(ROSA)26Sor<tm7(Pik3ca*,EGFP)Rsky>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4430527
• Gt(ROSA)26Sor<tm9(Rac1*,EGFP)Rsky>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4430551