decreased T cell number_Lck<tm1Mak>/Lck<tm1Mak>,Rag1<tm1Mom>/Rag1<+>,Tg(Lck-Fyn*Y528F)5525Cjg/0

http://metadb.riken.jp/0005018I129S2SvPas129S7SvEvBrdC57BL6Lcktm1MakLcktm1MakRag1tm1MomRag1TgLckFynY528F5525Cjg0Rag1TgLckFynY528F5525CjgRag1tm1MomLcktm1Mak

decreased T cell number_Lck<tm1Mak>/Lck<tm1Mak>,Rag1<tm1Mom>/Rag1<+>,Tg(Lck-Fyn*Y528F)5525Cjg/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• lymphocyte protein tyrosine kinase
  http://metadb.riken.jp/db/mgi_rdf/MGI:96756
• recombination activating gene 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97848
• transgene insertion 5525, Cynthia J Guidos
  http://metadb.riken.jp/db/mgi_rdf/MGI:4360313

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lck<tm1Mak>/Lck<tm1Mak>,Rag1<tm1Mom>/Rag1<+>,Tg(Lck-Fyn*Y528F)5525Cjg/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Rag1<+>|Tg(Lck-Fyn*Y528F)5525Cjg|Rag1<tm1Mom>|Lck<tm1Mak>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased T cell number
  http://purl.obolibrary.org/obo/MP_0005018

文献

http://purl.org/net/cito/citesAsAuthority

• T. Groves, et.al., Fyn can partially substitute for Lck in T lymphocyte development., Immunity, 1996, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/8934569