decreased double-negative T cell number_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0

http://metadb.riken.jp/0005089I129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgTcraHYTcrbHY71Vbo0TgCd4cre1CwiTgTcraHYTcrbHY71VboPlcg1tm1GcrpPlcg1tm1Rwen

decreased double-negative T cell number_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• phospholipase C, gamma 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97615
• transgene insertion 71, Harald von Boehmer
  http://metadb.riken.jp/db/mgi_rdf/MGI:3044559
• transgene insertion 1, Christopher B Wilson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448688

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Cd4-cre)1Cwi|Tg(TcraH-Y,TcrbH-Y)71Vbo|Plcg1<tm1Gcrp>|Plcg1<tm1Rwen>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129X1/SvJ * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased double-negative T cell number
  http://purl.obolibrary.org/obo/MP_0005089

文献

http://purl.org/net/cito/citesAsAuthority

• Guoping. Fu, et.al., Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance., The Journal of experimental medicine, 2010, 207
  http://rdf.ncbi.nlm.nih.gov/pubmed/20123962