Guoping. Fu, et.al., Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance., The Journal of experimental medicine, 2010, 207

http://rdf.ncbi.nlm.nih.gov/pubmed/20123962

Guoping. Fu, et.al., Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance., The Journal of experimental medicine, 2010, 207

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Plcg1<tm1Rwen>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437826

class

http://purl.org/net/cito/citesAsAuthority

• Plcg1<tm1Rwen>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4437826

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• rectal prolapse_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0000493I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• decreased body size_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001265EB6CgPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1CwiorI129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgCd4cre1CwiPlcg1tm1RwenPlcg1tm1Gcrp
• decreased interferon-gamma secretion_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008567I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• abnormal T cell activation_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001828I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• decreased interleukin-2 secretion_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008688I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• decreased body weight_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001262EB6CgPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1CwiorI129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgCd4cre1CwiPlcg1tm1RwenPlcg1tm1Gcrp
• increased CD8-positive, alpha-beta T cell number_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
  http://metadb.riken.jp/0008078I129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgTcraHYTcrbHY71Vbo0TgCd4cre1CwiTgTcraHYTcrbHY71VboPlcg1tm1GcrpPlcg1tm1Rwen
• dermatitis_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001194EB6CgPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1CwiorI129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgCd4cre1CwiPlcg1tm1RwenPlcg1tm1Gcrp
• increased T cell apoptosis_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0006413I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• abnormal CD8-positive, alpha-beta T cell differentiation_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008080I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• decreased body weight_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001262I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• decreased CD8-positive, alpha-beta T cell number_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008079I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• decreased T cell number_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005018EB6CgPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1CwiorI129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgCd4cre1CwiPlcg1tm1RwenPlcg1tm1Gcrp
• decreased single-positive T cell number_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008083I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• alopecia_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0000414EB6CgPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1CwiorI129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgCd4cre1CwiPlcg1tm1RwenPlcg1tm1Gcrp
• increased anti-double stranded DNA antibody level_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0004762EB6CgPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1CwiorI129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgCd4cre1CwiPlcg1tm1RwenPlcg1tm1Gcrp
• increased double-positive T cell number_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
  http://metadb.riken.jp/0005091I129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgTcraHYTcrbHY71Vbo0TgCd4cre1CwiTgTcraHYTcrbHY71VboPlcg1tm1GcrpPlcg1tm1Rwen
• increased double-positive T cell number_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005091I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• decreased T cell number_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005018I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• decreased regulatory T cell number_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0004974EB6CgPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1CwiorI129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgCd4cre1CwiPlcg1tm1RwenPlcg1tm1Gcrp
• abnormal T cell activation_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001828EB6CgPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1CwiorI129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgCd4cre1CwiPlcg1tm1RwenPlcg1tm1Gcrp
• increased CD4-positive, alpha beta T cell number_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008074EB6CgPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1CwiorI129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgCd4cre1CwiPlcg1tm1RwenPlcg1tm1Gcrp
• ear inflammation_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001849EB6CgPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1CwiorI129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgCd4cre1CwiPlcg1tm1RwenPlcg1tm1Gcrp
• dermatitis_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0001194I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• rectal prolapse_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0000493EB6CgPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1CwiorI129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgCd4cre1CwiPlcg1tm1RwenPlcg1tm1Gcrp
• decreased CD8-positive, alpha-beta T cell number_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
  http://metadb.riken.jp/0008079I129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgTcraHYTcrbHY71Vbo0TgCd4cre1CwiTgTcraHYTcrbHY71VboPlcg1tm1GcrpPlcg1tm1Rwen
• abnormal CD4-positive T cell differentiation_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008076I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• decreased double-negative T cell number_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
  http://metadb.riken.jp/0005089I129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgTcraHYTcrbHY71Vbo0TgCd4cre1CwiTgTcraHYTcrbHY71VboPlcg1tm1GcrpPlcg1tm1Rwen
• thymus hyperplasia_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
  http://metadb.riken.jp/0000708I129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgTcraHYTcrbHY71Vbo0TgCd4cre1CwiTgTcraHYTcrbHY71VboPlcg1tm1GcrpPlcg1tm1Rwen
• skin inflammation_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0004947EB6CgPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1CwiorI129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgCd4cre1CwiPlcg1tm1RwenPlcg1tm1Gcrp
• alopecia_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0000414I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• abnormal regulatory T cell physiology_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0004946I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• decreased CD4-positive, alpha beta T cell number_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0008075I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• decreased T cell proliferation_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005095I129X1SvJC57BL6DBA2GtROSA26Sortm1EYFPCosGtROSA26SorPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0Plcg1tm1GcrpPlcg1tm1RwenGtROSA26SorTgCd4cre1CwiGtROSA26Sortm1EYFPCos
• increased T cell proliferation_Plcg1<tm1Gcrp>/Plcg1<tm1Rwen>,Tg(Cd4-cre)1Cwi/0
  http://metadb.riken.jp/0005348EB6CgPlcg1tm1GcrpPlcg1tm1RwenTgCd4cre1CwiorI129X1SvJC57BL6DBA2Plcg1tm1GcrpPlcg1tm1RwenTgCd4cre1Cwi0TgCd4cre1CwiPlcg1tm1RwenPlcg1tm1Gcrp