decreased double-positive T cell number_Nr3c1<tm1.1Jda>/Nr3c1<tm1.1Jda>,Rag2<tm1.1Cgn>/Rag2<tm1.1Cgn>,Tg(Lck-cre)548Jxm/0,Tg(TcrAND)53Hed/0

http://metadb.riken.jp/0005092B6CgRag2tm11CgnNr3c1tm11JdaTgLckcre548JxmTgTcrAND53HedNr3c1tm11JdaNr3c1tm11JdaRag2tm11CgnRag2tm11CgnTgLckcre548Jxm0TgTcrAND53Hed0Rag2tm11CgnTgLckcre548JxmNr3c1tm11JdaTgTcrAND53Hed

decreased double-positive T cell number_Nr3c1<tm1.1Jda>/Nr3c1<tm1.1Jda>,Rag2<tm1.1Cgn>/Rag2<tm1.1Cgn>,Tg(Lck-cre)548Jxm/0,Tg(TcrAND)53Hed/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• recombination activating gene 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:97849
• nuclear receptor subfamily 3, group C, member 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:95824
• transgene insertion 53, Stephen M Hedrick
  http://metadb.riken.jp/db/mgi_rdf/MGI:3054631
• transgene insertion 548, Jamey Marth
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176198

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Nr3c1<tm1.1Jda>/Nr3c1<tm1.1Jda>,Rag2<tm1.1Cgn>/Rag2<tm1.1Cgn>,Tg(Lck-cre)548Jxm/0,Tg(TcrAND)53Hed/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Rag2<tm1.1Cgn>|Tg(Lck-cre)548Jxm|Nr3c1<tm1.1Jda>|Tg(TcrAND)53Hed

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• B6.Cg-Rag2<tm1.1Cgn> Nr3c1<tm1.1Jda> Tg(Lck-cre)548Jxm Tg(TcrAND)53Hed

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased double-positive T cell number
  http://purl.obolibrary.org/obo/MP_0005092

文献

http://purl.org/net/cito/citesAsAuthority

• Paul R. Mittelstadt, et.al., Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness., The Journal of clinical investigation, 2012, 122
  http://rdf.ncbi.nlm.nih.gov/pubmed/22653054