decreased double-positive T cell number_Ctla4<tm1Shr>/Ctla4<tm1Shr>

http://metadb.riken.jp/0005092EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr

decreased double-positive T cell number_Ctla4<tm1Shr>/Ctla4<tm1Shr>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cytotoxic T-lymphocyte-associated protein 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:88556

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ctla4<tm1Shr>/Ctla4<tm1Shr>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ctla4<tm1Shr>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased double-positive T cell number
  http://purl.obolibrary.org/obo/MP_0005092

文献

http://purl.org/net/cito/citesAsAuthority

• E A. Tivol, et.al., Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4., Immunity, 1995, 3
  http://rdf.ncbi.nlm.nih.gov/pubmed/7584144