E A. Tivol, et.al., Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4., Immunity, 1995, 3

http://rdf.ncbi.nlm.nih.gov/pubmed/7584144

E A. Tivol, et.al., Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4., Immunity, 1995, 3

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ctla4<tm1Shr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2180668

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal splenic cell ratio_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0008826EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• abnormal T cell morphology_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0008037EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• pancreas inflammation_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0001869EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• abnormal T cell differentiation_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0002145EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• increased double-negative T cell number_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0005090EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• enlarged spleen_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0000691EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• increased T cell number_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0005015EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• salivary gland inflammation_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0001870EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• premature death_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0002083EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• myocarditis_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0001856EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• joint inflammation_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0002933EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• increased T cell proliferation_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0005348EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• abnormal cytokine secretion_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0003009EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• decreased double-positive T cell number_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0005092EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• abnormal lymph node cell ratio_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0008828EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• lung inflammation_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0001861EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• enlarged lymph nodes_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0000702EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr
• vasculitis_Ctla4<tm1Shr>/Ctla4<tm1Shr>
  http://metadb.riken.jp/0001864EI129S4SvJaeBALBcorI129S4SvJaeC57BL6Ctla4tm1ShrCtla4tm1ShrCtla4tm1Shr

class

http://purl.org/net/cito/citesAsAuthority

• Ctla4<tm1Shr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:2180668