decreased double-positive T cell number_Crebbp<tm1Jvd>/Crebbp<tm1Jvd>,Ep300<tm2Pkb>/Ep300<tm2Pkb>,Tg(Lck-cre)548Jxm/0

http://metadb.riken.jp/0005092I129P2OlaHsdC57BL6CBACrebbptm1JvdCrebbptm1JvdEp300tm2PkbEp300tm2PkbTgLckcre548Jxm0Crebbptm1JvdTgLckcre548JxmEp300tm2Pkb

decreased double-positive T cell number_Crebbp<tm1Jvd>/Crebbp<tm1Jvd>,Ep300<tm2Pkb>/Ep300<tm2Pkb>,Tg(Lck-cre)548Jxm/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• E1A binding protein p300
  http://metadb.riken.jp/db/mgi_rdf/MGI:1276116
• CREB binding protein
  http://metadb.riken.jp/db/mgi_rdf/MGI:1098280
• transgene insertion 548, Jamey Marth
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176198

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Crebbp<tm1Jvd>/Crebbp<tm1Jvd>,Ep300<tm2Pkb>/Ep300<tm2Pkb>,Tg(Lck-cre)548Jxm/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Crebbp<tm1Jvd>|Tg(Lck-cre)548Jxm|Ep300<tm2Pkb>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased double-positive T cell number
  http://purl.obolibrary.org/obo/MP_0005092

文献

http://purl.org/net/cito/citesAsAuthority

• Lawryn H. Kasper, et.al., Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development., Molecular and cellular biology, 2006, 26
  http://rdf.ncbi.nlm.nih.gov/pubmed/16428436