decreased cardiac muscle contractility_Pak1<tm1.1Xwg>/Pak1<tm1.1Xwg>,Myl2<tm1(cre)Krc>/Myl2<+>

http://metadb.riken.jp/0005140I129S1Sv129S4SvJae129X1SvJC57BL6Pak1tm11XwgPak1tm11XwgMyl2tm1creKrcMyl2Myl2Pak1tm11XwgMyl2tm1creKrc

decreased cardiac muscle contractility_Pak1<tm1.1Xwg>/Pak1<tm1.1Xwg>,Myl2<tm1(cre)Krc>/Myl2<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• myosin, light polypeptide 2, regulatory, cardiac, slow
  http://metadb.riken.jp/db/mgi_rdf/MGI:97272
• p21 protein (Cdc42/Rac)-activated kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1339975

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pak1<tm1.1Xwg>/Pak1<tm1.1Xwg>,Myl2<tm1(cre)Krc>/Myl2<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Myl2<+>|Pak1<tm1.1Xwg>|Myl2<tm1(cre)Krc>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased cardiac muscle contractility
  http://purl.obolibrary.org/obo/MP_0005140

文献

http://purl.org/net/cito/citesAsAuthority

• Wei. Liu, et.al., Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart., Circulation, 2011, 124
  http://rdf.ncbi.nlm.nih.gov/pubmed/22082674