Wei. Liu, et.al., Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart., Circulation, 2011, 124

http://rdf.ncbi.nlm.nih.gov/pubmed/22082674

Wei. Liu, et.al., Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart., Circulation, 2011, 124

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Pak1<tm1.1Xwg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5470058

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• enlarged myocardial fiber_Pak1<tm1.1Xwg>/Pak1<tm1.1Xwg>,Myl2<tm1(cre)Krc>/Myl2<+>
  http://metadb.riken.jp/0004564I129S1Sv129S4SvJae129X1SvJC57BL6Pak1tm11XwgPak1tm11XwgMyl2tm1creKrcMyl2Myl2Pak1tm11XwgMyl2tm1creKrc
• cardiac hypertrophy_Pak1<tm1.1Xwg>/Pak1<tm1.1Xwg>,Myl2<tm1(cre)Krc>/Myl2<+>
  http://metadb.riken.jp/0001625I129S1Sv129S4SvJae129X1SvJC57BL6Pak1tm11XwgPak1tm11XwgMyl2tm1creKrcMyl2Myl2Pak1tm11XwgMyl2tm1creKrc
• increased response of heart to induced stress_Pak1<tm1.1Xwg>/Pak1<tm1.1Xwg>,Myl2<tm1(cre)Krc>/Myl2<+>
  http://metadb.riken.jp/0004485I129S1Sv129S4SvJae129X1SvJC57BL6Pak1tm11XwgPak1tm11XwgMyl2tm1creKrcMyl2Myl2Pak1tm11XwgMyl2tm1creKrc
• congestive heart failure_Pak1<tm1.1Xwg>/Pak1<tm1.1Xwg>,Myl2<tm1(cre)Krc>/Myl2<+>
  http://metadb.riken.jp/0006138I129S1Sv129S4SvJae129X1SvJC57BL6Pak1tm11XwgPak1tm11XwgMyl2tm1creKrcMyl2Myl2Pak1tm11XwgMyl2tm1creKrc
• pulmonary edema_Pak1<tm1.1Xwg>/Pak1<tm1.1Xwg>,Myl2<tm1(cre)Krc>/Myl2<+>
  http://metadb.riken.jp/0003828I129S1Sv129S4SvJae129X1SvJC57BL6Pak1tm11XwgPak1tm11XwgMyl2tm1creKrcMyl2Myl2Pak1tm11XwgMyl2tm1creKrc
• increased cardiomyocyte apoptosis_Pak1<tm1.1Xwg>/Pak1<tm1.1Xwg>,Myl2<tm1(cre)Krc>/Myl2<+>
  http://metadb.riken.jp/0003222I129S1Sv129S4SvJae129X1SvJC57BL6Pak1tm11XwgPak1tm11XwgMyl2tm1creKrcMyl2Myl2Pak1tm11XwgMyl2tm1creKrc
• no abnormal phenotype detected_Pak1<tm1.1Xwg>/Pak1<tm1.1Xwg>
  http://metadb.riken.jp/0002169B6129Pak1tm11XwgPak1tm11XwgPak1tm11XwgPak1tm11Xwg
• cardiac fibrosis_Pak1<tm1.1Xwg>/Pak1<tm1.1Xwg>,Myl2<tm1(cre)Krc>/Myl2<+>
  http://metadb.riken.jp/0003141I129S1Sv129S4SvJae129X1SvJC57BL6Pak1tm11XwgPak1tm11XwgMyl2tm1creKrcMyl2Myl2Pak1tm11XwgMyl2tm1creKrc
• decreased cardiac muscle contractility_Pak1<tm1.1Xwg>/Pak1<tm1.1Xwg>,Myl2<tm1(cre)Krc>/Myl2<+>
  http://metadb.riken.jp/0005140I129S1Sv129S4SvJae129X1SvJC57BL6Pak1tm11XwgPak1tm11XwgMyl2tm1creKrcMyl2Myl2Pak1tm11XwgMyl2tm1creKrc
• increased heart weight_Pak1<tm1.1Xwg>/Pak1<tm1.1Xwg>,Myl2<tm1(cre)Krc>/Myl2<+>
  http://metadb.riken.jp/0002833I129S1Sv129S4SvJae129X1SvJC57BL6Pak1tm11XwgPak1tm11XwgMyl2tm1creKrcMyl2Myl2Pak1tm11XwgMyl2tm1creKrc

class

http://purl.org/net/cito/citesAsAuthority

• Pak1<tm1.1Xwg>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5470058