holoprosencephaly_Six3<tm3Gco>/Six3<tm3Gco>,Foxg1<tm1(cre)Skm>/Foxg1<+>

http://metadb.riken.jp/0005157I129S1SvC57BL6Six3tm3GcoSix3tm3GcoFoxg1tm1creSkmFoxg1Foxg1tm1creSkmFoxg1Six3tm3Gco

holoprosencephaly_Six3<tm3Gco>/Six3<tm3Gco>,Foxg1<tm1(cre)Skm>/Foxg1<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• forkhead box G1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1347464
• sine oculis-related homeobox 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:102764

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Six3<tm3Gco>/Six3<tm3Gco>,Foxg1<tm1(cre)Skm>/Foxg1<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Foxg1<tm1(cre)Skm>|Foxg1<+>|Six3<tm3Gco>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• holoprosencephaly
  http://purl.obolibrary.org/obo/MP_0005157

文献

http://purl.org/net/cito/citesAsAuthority

• Xin. Geng, et.al., Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly., Developmental cell, 2008, 15
  http://rdf.ncbi.nlm.nih.gov/pubmed/18694563