Xin. Geng, et.al., Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly., Developmental cell, 2008, 15

http://rdf.ncbi.nlm.nih.gov/pubmed/18694563

Xin. Geng, et.al., Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly., Developmental cell, 2008, 15

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Six3<tm3Gco>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3814869
• Six3<tm3.1Gco>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3814870
• Six3<tm4(cre/ERT2)Gco>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3814875

class

http://purl.org/net/cito/citesAsAuthority

• Six3<tm3Gco>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3814869
• Six3<tm3.1Gco>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3814870
• Six3<tm4(cre/ERT2)Gco>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3814875

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• microcephaly_Six3<tm3.1Gco>/Six3<+>,Shh<tm1Chg>/Shh<+>
  http://metadb.riken.jp/0000433I129S1Sv129X1SvJC57BL6Six3tm31GcoSix3Shhtm1ChgShhShhSix3tm31GcoShhtm1ChgSix3
• abnormal telencephalon morphology_Six3<tm3.1Gco>/Six3<+>,Shh<tm1Chg>/Shh<+>
  http://metadb.riken.jp/0000787I129S1Sv129X1SvJC57BL6Six3tm31GcoSix3Shhtm1ChgShhShhSix3tm31GcoShhtm1ChgSix3
• absent corpus callosum_Six3<tm3.1Gco>/Six3<+>,Shh<tm1Chg>/Shh<+>
  http://metadb.riken.jp/0002196I129S1Sv129X1SvJC57BL6Six3tm31GcoSix3Shhtm1ChgShhShhSix3tm31GcoShhtm1ChgSix3
• abnormal optic stalk morphology_Six3<tm3.1Gco>/Six3<+>,Shh<tm1Chg>/Shh<+>
  http://metadb.riken.jp/0004268I129S1Sv129X1SvJC57BL6Six3tm31GcoSix3Shhtm1ChgShhShhSix3tm31GcoShhtm1ChgSix3
• absent nasal septum_Six3<tm3.1Gco>/Six3<+>,Shh<tm1Chg>/Shh<+>
  http://metadb.riken.jp/0004872I129S1Sv129X1SvJC57BL6Six3tm31GcoSix3Shhtm1ChgShhShhSix3tm31GcoShhtm1ChgSix3
• holoprosencephaly_Six3<tm3.1Gco>/Six3<+>,Shh<tm1Chg>/Shh<+>
  http://metadb.riken.jp/0005157I129S1Sv129X1SvJC57BL6Six3tm31GcoSix3Shhtm1ChgShhShhSix3tm31GcoShhtm1ChgSix3
他8件を見る
• holoprosencephaly_Six3<tm3Gco>/Six3<tm3Gco>,Foxg1<tm1(cre)Skm>/Foxg1<+>
  http://metadb.riken.jp/0005157I129S1SvC57BL6Six3tm3GcoSix3tm3GcoFoxg1tm1creSkmFoxg1Foxg1tm1creSkmFoxg1Six3tm3Gco
• holoprosencephaly_Six3<tm4(cre/ERT2)Gco>/Six3<+>
  http://metadb.riken.jp/0005157I129S1SvC57BL6Six3tm4creERT2GcoSix3Six3tm4creERT2GcoSix3
• ocular hypotelorism_Six3<tm3.1Gco>/Six3<+>,Shh<tm1Chg>/Shh<+>
  http://metadb.riken.jp/0006197I129S1Sv129X1SvJC57BL6Six3tm31GcoSix3Shhtm1ChgShhShhSix3tm31GcoShhtm1ChgSix3
• abnormal cerebral hemisphere morphology_Six3<tm3.1Gco>/Six3<+>,Shh<tm1Chg>/Shh<+>
  http://metadb.riken.jp/0008540I129S1Sv129X1SvJC57BL6Six3tm31GcoSix3Shhtm1ChgShhShhSix3tm31GcoShhtm1ChgSix3
• abnormal palatal shelf fusion at midline_Six3<tm3.1Gco>/Six3<+>,Shh<tm1Chg>/Shh<+>
  http://metadb.riken.jp/0009887I129S1Sv129X1SvJC57BL6Six3tm31GcoSix3Shhtm1ChgShhShhSix3tm31GcoShhtm1ChgSix3
• abnormal medial nasal prominence morphology_Six3<tm3.1Gco>/Six3<+>,Shh<tm1Chg>/Shh<+>
  http://metadb.riken.jp/0009903I129S1Sv129X1SvJC57BL6Six3tm31GcoSix3Shhtm1ChgShhShhSix3tm31GcoShhtm1ChgSix3
• olfactory bulb hypoplasia_Six3<tm3.1Gco>/Six3<+>,Shh<tm1Chg>/Shh<+>
  http://metadb.riken.jp/0010059I129S1Sv129X1SvJC57BL6Six3tm31GcoSix3Shhtm1ChgShhShhSix3tm31GcoShhtm1ChgSix3
• absent philtrum_Six3<tm3.1Gco>/Six3<+>,Shh<tm1Chg>/Shh<+>
  http://metadb.riken.jp/0012257I129S1Sv129X1SvJC57BL6Six3tm31GcoSix3Shhtm1ChgShhShhSix3tm31GcoShhtm1ChgSix3