increased susceptibility to injury_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras2)12Hev/0

http://metadb.riken.jp/0005165I129S1Sv129X1SvJC57BL6JFVBNGtROSA26Sortm1rtTAEGFPNagyGtROSA26SorPtf1atm11creCvwPtf1aTgtetOKras212Hev0GtROSA26SorPtf1aTgtetOKras212HevGtROSA26Sortm1rtTAEGFPNagyPtf1atm11creCvw

increased susceptibility to injury_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras2)12Hev/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 12, Harold E Varmus
  http://metadb.riken.jp/db/mgi_rdf/MGI:2179991
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• pancreas specific transcription factor, 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328312

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras2)12Hev/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<+>|Ptf1a<+>|Tg(tetO-Kras2)12Hev|Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>|Ptf1a<tm1.1(cre)Cvw>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased susceptibility to injury
  http://purl.obolibrary.org/obo/MP_0005165

文献

http://purl.org/net/cito/citesAsAuthority

• Meredith A. Collins, et.al., Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice., The Journal of clinical investigation, 2012, 122
  http://rdf.ncbi.nlm.nih.gov/pubmed/22232209