Meredith A. Collins, et.al., Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice., The Journal of clinical investigation, 2012, 122

http://rdf.ncbi.nlm.nih.gov/pubmed/22232209

Meredith A. Collins, et.al., Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice., The Journal of clinical investigation, 2012, 122

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased pancreatic intraepithelial neoplasia incidence_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras2)12Hev/0,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0009152I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNGtROSA26Sortm1rtTAEGFPNagyGtROSA26SorPtf1atm11creCvwPtf1aTgtetOKras212Hev0Trp53tm1TyjTrp53Ptf1aGtROSA26SorTrp53tm1TyjTrp53Ptf1atm11creCvwGtROSA26Sortm1rtTAEGFPNagyTgtetOKras212Hev
• small pancreas_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras2)12Hev/0
  http://metadb.riken.jp/0004247I129S1Sv129X1SvJC57BL6JFVBNGtROSA26Sortm1rtTAEGFPNagyGtROSA26SorPtf1atm11creCvwPtf1aTgtetOKras212Hev0GtROSA26SorPtf1aTgtetOKras212HevGtROSA26Sortm1rtTAEGFPNagyPtf1atm11creCvw
• premature death_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras2)12Hev/0,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002083I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNGtROSA26Sortm1rtTAEGFPNagyGtROSA26SorPtf1atm11creCvwPtf1aTgtetOKras212Hev0Trp53tm1TyjTrp53Ptf1aGtROSA26SorTrp53tm1TyjTrp53Ptf1atm11creCvwGtROSA26Sortm1rtTAEGFPNagyTgtetOKras212Hev
• increased pancreatic ductal adenocarcinoma incidence_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras2)12Hev/0,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0009151I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNGtROSA26Sortm1rtTAEGFPNagyGtROSA26SorPtf1atm11creCvwPtf1aTgtetOKras212Hev0Trp53tm1TyjTrp53Ptf1aGtROSA26SorTrp53tm1TyjTrp53Ptf1atm11creCvwGtROSA26Sortm1rtTAEGFPNagyTgtetOKras212Hev
• increased susceptibility to injury_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras2)12Hev/0
  http://metadb.riken.jp/0005165I129S1Sv129X1SvJC57BL6JFVBNGtROSA26Sortm1rtTAEGFPNagyGtROSA26SorPtf1atm11creCvwPtf1aTgtetOKras212Hev0GtROSA26SorPtf1aTgtetOKras212HevGtROSA26Sortm1rtTAEGFPNagyPtf1atm11creCvw
• pancreatic acinar-to-ductal metaplasia_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras2)12Hev/0
  http://metadb.riken.jp/0013221I129S1Sv129X1SvJC57BL6JFVBNGtROSA26Sortm1rtTAEGFPNagyGtROSA26SorPtf1atm11creCvwPtf1aTgtetOKras212Hev0GtROSA26SorPtf1aTgtetOKras212HevGtROSA26Sortm1rtTAEGFPNagyPtf1atm11creCvw
• increased pancreas tumor incidence_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras2)12Hev/0
  http://metadb.riken.jp/0009153I129S1Sv129X1SvJC57BL6JFVBNGtROSA26Sortm1rtTAEGFPNagyGtROSA26SorPtf1atm11creCvwPtf1aTgtetOKras212Hev0GtROSA26SorPtf1aTgtetOKras212HevGtROSA26Sortm1rtTAEGFPNagyPtf1atm11creCvw
• increased pancreatic intraepithelial neoplasia incidence_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras2)12Hev/0
  http://metadb.riken.jp/0009152I129S1Sv129X1SvJC57BL6JFVBNGtROSA26Sortm1rtTAEGFPNagyGtROSA26SorPtf1atm11creCvwPtf1aTgtetOKras212Hev0GtROSA26SorPtf1aTgtetOKras212HevGtROSA26Sortm1rtTAEGFPNagyPtf1atm11creCvw
• increased susceptibility to injury_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(tetO-Kras2)12Hev/0,Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0005165I129S1Sv129S2SvPas129X1SvJC57BL6JFVBNGtROSA26Sortm1rtTAEGFPNagyGtROSA26SorPtf1atm11creCvwPtf1aTgtetOKras212Hev0Trp53tm1TyjTrp53Ptf1aGtROSA26SorTrp53tm1TyjTrp53Ptf1atm11creCvwGtROSA26Sortm1rtTAEGFPNagyTgtetOKras212Hev