decreased circulating cholesterol level_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0

http://metadb.riken.jp/0005179I129S1Sv129X1SvJC57BL6DBAFVBFoxo1tm1RdpFoxo1tm1RdpIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21MgnFoxo1tm1Rdp

decreased circulating cholesterol level_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• insulin receptor substrate 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:109334
• insulin receptor substrate 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:99454
• forkhead box O1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1890077
• transgene insertion 21, Mark A Magnuson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176226

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Irs2<tm2Mfw>|Irs1<tm1Mfw>|Tg(Alb-cre)21Mgn|Foxo1<tm1Rdp>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA * FVB

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased circulating cholesterol level
  http://purl.obolibrary.org/obo/MP_0005179

文献

http://purl.org/net/cito/citesAsAuthority

• Xiaocheng C. Dong, et.al., Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation., Cell metabolism, 2008, 8
  http://rdf.ncbi.nlm.nih.gov/pubmed/18590693