Xiaocheng C. Dong, et.al., Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation., Cell metabolism, 2008, 8

http://rdf.ncbi.nlm.nih.gov/pubmed/18590693

Xiaocheng C. Dong, et.al., Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation., Cell metabolism, 2008, 8

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Irs1<tm1Mfw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3803962

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased circulating cholesterol level_Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005179I129S1Sv129X1SvJC57BL6DBAIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21Mgn
• decreased circulating cholesterol level_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005179I129S1Sv129X1SvJC57BL6DBAFVBFoxo1tm1RdpFoxo1tm1RdpIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21MgnFoxo1tm1Rdp
• decreased body size_Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0001265I129S1Sv129X1SvJC57BL6DBAIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21Mgn
• decreased circulating free fatty acid level_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002702I129S1Sv129X1SvJC57BL6DBAFVBFoxo1tm1RdpFoxo1tm1RdpIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21MgnFoxo1tm1Rdp
• improved glucose tolerance_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005292I129S1SvC57BL6DBAFVBFoxo1tm1RdpFoxo1tm1RdpTgAlbcre21Mgn0TgAlbcre21MgnFoxo1tm1Rdp
• impaired glucose tolerance_Irs1<tm1Mfw>/Irs1<tm1Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005293I129S1Sv129X1SvJC57BL6DBAIrs1tm1MfwIrs1tm1MfwTgAlbcre21Mgn0Irs1tm1MfwTgAlbcre21Mgn
• decreased circulating triglyceride level_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002644I129S1Sv129X1SvJC57BL6DBAFVBFoxo1tm1RdpFoxo1tm1RdpIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21MgnFoxo1tm1Rdp
• decreased circulating free fatty acid level_Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002702I129S1Sv129X1SvJC57BL6DBAIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21Mgn
• impaired glucose tolerance_Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005293I129S1Sv129X1SvJC57BL6DBAIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21Mgn
• increased circulating glucose level_Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005559I129S1Sv129X1SvJC57BL6DBAIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21Mgn
• hyperglycemia_Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0001559I129S1Sv129X1SvJC57BL6DBAIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21Mgn
• increased susceptibility to autoimmune diabetes_Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0004803I129S1Sv129X1SvJC57BL6DBAIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21Mgn
• abnormal triglyceride level_Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000187I129S1Sv129X1SvJC57BL6DBAIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21Mgn
• decreased circulating triglyceride level_Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002644I129S1Sv129X1SvJC57BL6DBAIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21Mgn
• decreased glycogen level_Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005439I129S1Sv129X1SvJC57BL6DBAIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21Mgn
• abnormal triglyceride level_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000187I129S1Sv129X1SvJC57BL6DBAFVBFoxo1tm1RdpFoxo1tm1RdpIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21MgnFoxo1tm1Rdp
• decreased circulating HDL cholesterol level_Foxo1<tm1Rdp>/Foxo1<tm1Rdp>,Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000186I129S1Sv129X1SvJC57BL6DBAFVBFoxo1tm1RdpFoxo1tm1RdpIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21MgnFoxo1tm1Rdp
• insulin resistance_Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0005331I129S1Sv129X1SvJC57BL6DBAIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21Mgn
• decreased circulating HDL cholesterol level_Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0000186I129S1Sv129X1SvJC57BL6DBAIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21Mgn
• increased circulating insulin level_Irs1<tm1Mfw>/Irs1<tm1Mfw>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0
  http://metadb.riken.jp/0002079I129S1Sv129X1SvJC57BL6DBAIrs1tm1MfwIrs1tm1MfwIrs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1tm1MfwTgAlbcre21Mgn

class

http://purl.org/net/cito/citesAsAuthority

• Irs1<tm1Mfw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3803962