decreased circulating estradiol level_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Kras<tm4Tyj>/Kras<+>,Tg(CYP19A1-cre)1Jri/0

http://metadb.riken.jp/0005181I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Krastm4TyjKrasTgCYP19A1cre1Jri0Krastm4TyjTgCYP19A1cre1JriCtnnb1KrasCtnnb1tm1Mmt

decreased circulating estradiol level_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Kras<tm4Tyj>/Kras<+>,Tg(CYP19A1-cre)1Jri/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• transgene insertion 1, JoAnne Richards
  http://metadb.riken.jp/db/mgi_rdf/MGI:3799680
• catenin (cadherin associated protein), beta 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88276

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ctnnb1<tm1Mmt>/Ctnnb1<+>,Kras<tm4Tyj>/Kras<+>,Tg(CYP19A1-cre)1Jri/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kras<tm4Tyj>|Tg(CYP19A1-cre)1Jri|Ctnnb1<+>|Kras<+>|Ctnnb1<tm1Mmt>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased circulating estradiol level
  http://purl.obolibrary.org/obo/MP_0005181

文献

http://purl.org/net/cito/citesAsAuthority

• J S. Richards, et.al., Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis., Oncogene, 2012, 31
  http://rdf.ncbi.nlm.nih.gov/pubmed/21860425