J S. Richards, et.al., Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis., Oncogene, 2012, 31

http://rdf.ncbi.nlm.nih.gov/pubmed/21860425

J S. Richards, et.al., Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis., Oncogene, 2012, 31

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased granulosa cell tumor incidence_Amhr2<tm3(cre)Bhr>/Amhr2<+>,Ctnnb1<tm1Mmt>/Ctnnb1<+>
  http://metadb.riken.jp/0012411I129S7SvEvBrd129X1SvJC57BL6Amhr2tm3creBhrAmhr2Ctnnb1tm1MmtCtnnb1Amhr2Ctnnb1Ctnnb1tm1MmtAmhr2tm3creBhr
• increased testis tumor incidence_Amhr2<tm3(cre)Bhr>/Amhr2<+>,Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>
  http://metadb.riken.jp/0006262I129S4SvJae129S7SvEvBrd129X1SvJC57BL6Amhr2tm3creBhrAmhr2Ctnnb1tm1MmtCtnnb1Ptentm1HwuPtentm1HwuAmhr2Ctnnb1tm1MmtCtnnb1Amhr2tm3creBhrPtentm1Hwu
• increased granulosa cell tumor incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0012411I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Ptentm1HwuPtentm1HwuTgCYP19A1cre1Jri0Ptentm1HwuCtnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri
• male infertility_Amhr2<tm3(cre)Bhr>/Amhr2<+>,Ctnnb1<tm1Mmt>/Ctnnb1<+>
  http://metadb.riken.jp/0001925I129S7SvEvBrd129X1SvJC57BL6Amhr2tm3creBhrAmhr2Ctnnb1tm1MmtCtnnb1Amhr2Ctnnb1Ctnnb1tm1MmtAmhr2tm3creBhr
• increased testis tumor incidence_Amhr2<tm3(cre)Bhr>/Amhr2<+>,Ctnnb1<tm1Mmt>/Ctnnb1<+>
  http://metadb.riken.jp/0006262I129S7SvEvBrd129X1SvJC57BL6Amhr2tm3creBhrAmhr2Ctnnb1tm1MmtCtnnb1Amhr2Ctnnb1Ctnnb1tm1MmtAmhr2tm3creBhr
• increased granulosa cell tumor incidence_Amhr2<tm3(cre)Bhr>/Amhr2<+>,Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>
  http://metadb.riken.jp/0012411I129S4SvJae129S7SvEvBrd129X1SvJC57BL6Amhr2tm3creBhrAmhr2Ctnnb1tm1MmtCtnnb1Ptentm1HwuPtentm1HwuAmhr2Ctnnb1tm1MmtCtnnb1Amhr2tm3creBhrPtentm1Hwu
• seminiferous tubule degeneration_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Kras<tm4Tyj>/Kras<+>,Amhr2<tm3(cre)Bhr>/Amhr2<+>
  http://metadb.riken.jp/0001154I129S4SvJae129S7SvEvBrd129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Krastm4TyjKrasAmhr2tm3creBhrAmhr2Amhr2tm3creBhrKrastm4TyjCtnnb1tm1MmtKrasCtnnb1Amhr2
• premature death_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0002083I129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri0Ctnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri
• decreased circulating progesterone level_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0005185I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Ptentm1HwuPtentm1HwuTgCYP19A1cre1Jri0Ptentm1HwuCtnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri
• increased granulosa cell tumor incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Kras<tm4Tyj>/Kras<+>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0012411I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Krastm4TyjKrasTgCYP19A1cre1Jri0Krastm4TyjTgCYP19A1cre1JriCtnnb1KrasCtnnb1tm1Mmt
• increased ovary tumor incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0008000I129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri0Ctnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri
• impaired granulosa cell differentiation_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Kras<tm4Tyj>/Kras<+>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0003357I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Krastm4TyjKrasTgCYP19A1cre1Jri0Krastm4TyjTgCYP19A1cre1JriCtnnb1KrasCtnnb1tm1Mmt
• decreased circulating progesterone level_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Kras<tm4Tyj>/Kras<+>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0005185I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Krastm4TyjKrasTgCYP19A1cre1Jri0Krastm4TyjTgCYP19A1cre1JriCtnnb1KrasCtnnb1tm1Mmt
• premature death_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Kras<tm4Tyj>/Kras<+>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0002083I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Krastm4TyjKrasTgCYP19A1cre1Jri0Krastm4TyjTgCYP19A1cre1JriCtnnb1KrasCtnnb1tm1Mmt
• premature death_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0002083I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Ptentm1HwuPtentm1HwuTgCYP19A1cre1Jri0Ptentm1HwuCtnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri
• decreased circulating estradiol level_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0005181I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Ptentm1HwuPtentm1HwuTgCYP19A1cre1Jri0Ptentm1HwuCtnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri
• increased circulating follicle stimulating hormone level_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Kras<tm4Tyj>/Kras<+>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0001750I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Krastm4TyjKrasTgCYP19A1cre1Jri0Krastm4TyjTgCYP19A1cre1JriCtnnb1KrasCtnnb1tm1Mmt
• increased granulosa cell tumor incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0012411I129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri0Ctnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri
• increased ovary tumor incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Kras<tm4Tyj>/Kras<+>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0008000I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Krastm4TyjKrasTgCYP19A1cre1Jri0Krastm4TyjTgCYP19A1cre1JriCtnnb1KrasCtnnb1tm1Mmt
• abnormal granulosa cell morphology_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0008868I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Ptentm1HwuPtentm1HwuTgCYP19A1cre1Jri0Ptentm1HwuCtnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri
• increased circulating luteinizing hormone level_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0001751I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Ptentm1HwuPtentm1HwuTgCYP19A1cre1Jri0Ptentm1HwuCtnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri
• impaired granulosa cell differentiation_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0003357I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Ptentm1HwuPtentm1HwuTgCYP19A1cre1Jri0Ptentm1HwuCtnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri
• increased granulosa cell tumor incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Kras<tm4Tyj>/Kras<+>,Amhr2<tm3(cre)Bhr>/Amhr2<+>
  http://metadb.riken.jp/0012411I129S4SvJae129S7SvEvBrd129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Krastm4TyjKrasAmhr2tm3creBhrAmhr2Amhr2tm3creBhrKrastm4TyjCtnnb1tm1MmtKrasCtnnb1Amhr2
• seminiferous tubule degeneration_Amhr2<tm3(cre)Bhr>/Amhr2<+>,Ctnnb1<tm1Mmt>/Ctnnb1<+>
  http://metadb.riken.jp/0001154I129S7SvEvBrd129X1SvJC57BL6Amhr2tm3creBhrAmhr2Ctnnb1tm1MmtCtnnb1Amhr2Ctnnb1Ctnnb1tm1MmtAmhr2tm3creBhr
• increased testis tumor incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Kras<tm4Tyj>/Kras<+>,Amhr2<tm3(cre)Bhr>/Amhr2<+>
  http://metadb.riken.jp/0006262I129S4SvJae129S7SvEvBrd129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Krastm4TyjKrasAmhr2tm3creBhrAmhr2Amhr2tm3creBhrKrastm4TyjCtnnb1tm1MmtKrasCtnnb1Amhr2
• increased circulating follicle stimulating hormone level_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0001750I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Ptentm1HwuPtentm1HwuTgCYP19A1cre1Jri0Ptentm1HwuCtnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri
• increased circulating luteinizing hormone level_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Kras<tm4Tyj>/Kras<+>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0001751I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Krastm4TyjKrasTgCYP19A1cre1Jri0Krastm4TyjTgCYP19A1cre1JriCtnnb1KrasCtnnb1tm1Mmt
• testicular atrophy_Amhr2<tm3(cre)Bhr>/Amhr2<+>,Ctnnb1<tm1Mmt>/Ctnnb1<+>
  http://metadb.riken.jp/0003205I129S7SvEvBrd129X1SvJC57BL6Amhr2tm3creBhrAmhr2Ctnnb1tm1MmtCtnnb1Amhr2Ctnnb1Ctnnb1tm1MmtAmhr2tm3creBhr
• increased ovary tumor incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0008000I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Ptentm1HwuPtentm1HwuTgCYP19A1cre1Jri0Ptentm1HwuCtnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri
• decreased circulating estradiol level_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Kras<tm4Tyj>/Kras<+>,Tg(CYP19A1-cre)1Jri/0
  http://metadb.riken.jp/0005181I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Krastm4TyjKrasTgCYP19A1cre1Jri0Krastm4TyjTgCYP19A1cre1JriCtnnb1KrasCtnnb1tm1Mmt