abnormal pancreatic islet morphology_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Hprt<tm1(Ins2-HBEGF)Herr>/Y,Tg(Ins2-cre/ERT)1Dam/0

http://metadb.riken.jp/0005215I129X1SvJC57BL6CBAGtROSA26Sortm1EYFPCosGtROSA26SorHprttm1Ins2HBEGFHerrYTgIns2creERT1Dam0TgIns2creERT1DamGtROSA26SorHprttm1Ins2HBEGFHerrGtROSA26Sortm1EYFPCos

abnormal pancreatic islet morphology_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Hprt<tm1(Ins2-HBEGF)Herr>/Y,Tg(Ins2-cre/ERT)1Dam/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 1, Douglas A Melton
  http://metadb.riken.jp/db/mgi_rdf/MGI:3720950
• hypoxanthine guanine phosphoribosyl transferase
  http://metadb.riken.jp/db/mgi_rdf/MGI:96217

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Hprt<tm1(Ins2-HBEGF)Herr>/Y,Tg(Ins2-cre/ERT)1Dam/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Ins2-cre/ERT)1Dam|Gt(ROSA)26Sor<+>|Hprt<tm1(Ins2-HBEGF)Herr>|Gt(ROSA)26Sor<tm1(EYFP)Cos>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129X1/SvJ * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal pancreatic islet morphology
  http://purl.obolibrary.org/obo/MP_0005215

文献

http://purl.org/net/cito/citesAsAuthority

• Fabrizio. Thorel, et.al., Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss., Nature, 2010, 464
  http://rdf.ncbi.nlm.nih.gov/pubmed/20364121