Fabrizio. Thorel, et.al., Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss., Nature, 2010, 464

http://rdf.ncbi.nlm.nih.gov/pubmed/20364121

Fabrizio. Thorel, et.al., Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss., Nature, 2010, 464

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Hprt<tm1(Ins2-HBEGF)Herr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5567081
• Tg(Gcg-HBEGF)#Herr
  http://metadb.riken.jp/db/mgi_rdf/MGI:5567082
• Tg(Gcg-rtTA)#Herr
  http://metadb.riken.jp/db/mgi_rdf/MGI:5567083

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• weight loss_Hprt<tm1(Ins2-HBEGF)Herr>/Y
  http://metadb.riken.jp/0001263I129C57BL6Hprttm1Ins2HBEGFHerrYHprttm1Ins2HBEGFHerr
• polydipsia_Hprt<tm1(Ins2-HBEGF)Herr>/Y
  http://metadb.riken.jp/0001426I129C57BL6Hprttm1Ins2HBEGFHerrYHprttm1Ins2HBEGFHerr
• hyperglycemia_Hprt<tm1(Ins2-HBEGF)Herr>/Hprt<tm1(Ins2-HBEGF)Herr>
  http://metadb.riken.jp/0001559I129C57BL6Hprttm1Ins2HBEGFHerrHprttm1Ins2HBEGFHerrHprttm1Ins2HBEGFHerr
• hyperglycemia_Hprt<tm1(Ins2-HBEGF)Herr>/Y
  http://metadb.riken.jp/0001559I129C57BL6Hprttm1Ins2HBEGFHerrYHprttm1Ins2HBEGFHerr
• polyuria_Hprt<tm1(Ins2-HBEGF)Herr>/Y
  http://metadb.riken.jp/0001762I129C57BL6Hprttm1Ins2HBEGFHerrYHprttm1Ins2HBEGFHerr
• premature death_Hprt<tm1(Ins2-HBEGF)Herr>/Y
  http://metadb.riken.jp/0002083I129C57BL6Hprttm1Ins2HBEGFHerrYHprttm1Ins2HBEGFHerr
他10件を見る
• increased circulating ketone body level_Hprt<tm1(Ins2-HBEGF)Herr>/Y
  http://metadb.riken.jp/0002575I129C57BL6Hprttm1Ins2HBEGFHerrYHprttm1Ins2HBEGFHerr
• increased insulin secretion_Hprt<tm1(Ins2-HBEGF)Herr>/Y
  http://metadb.riken.jp/0003058I129C57BL6Hprttm1Ins2HBEGFHerrYHprttm1Ins2HBEGFHerr
• decreased insulin secretion_Hprt<tm1(Ins2-HBEGF)Herr>/Y
  http://metadb.riken.jp/0003059I129C57BL6Hprttm1Ins2HBEGFHerrYHprttm1Ins2HBEGFHerr
• decreased pancreatic beta cell number_Hprt<tm1(Ins2-HBEGF)Herr>/Y
  http://metadb.riken.jp/0003339I129C57BL6Hprttm1Ins2HBEGFHerrYHprttm1Ins2HBEGFHerr
• abnormal pancreatic beta cell physiology_Hprt<tm1(Ins2-HBEGF)Herr>/Y
  http://metadb.riken.jp/0003562I129C57BL6Hprttm1Ins2HBEGFHerrYHprttm1Ins2HBEGFHerr
• abnormal pancreatic islet morphology_Hprt<tm1(Ins2-HBEGF)Herr>/Y
  http://metadb.riken.jp/0005215I129C57BL6Hprttm1Ins2HBEGFHerrYHprttm1Ins2HBEGFHerr
• abnormal pancreatic islet morphology_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Hprt<tm1(Ins2-HBEGF)Herr>/Y,Tg(Ins2-cre/ERT)1Dam/0
  http://metadb.riken.jp/0005215I129X1SvJC57BL6CBAGtROSA26Sortm1EYFPCosGtROSA26SorHprttm1Ins2HBEGFHerrYTgIns2creERT1Dam0TgIns2creERT1DamGtROSA26SorHprttm1Ins2HBEGFHerrGtROSA26Sortm1EYFPCos
• increased pancreatic beta cell mass_Hprt<tm1(Ins2-HBEGF)Herr>/Y
  http://metadb.riken.jp/0009113I129C57BL6Hprttm1Ins2HBEGFHerrYHprttm1Ins2HBEGFHerr
• decreased pancreatic beta cell mass_Hprt<tm1(Ins2-HBEGF)Herr>/Y
  http://metadb.riken.jp/0009114I129C57BL6Hprttm1Ins2HBEGFHerrYHprttm1Ins2HBEGFHerr
• abnormal pancreatic alpha cell differentiation_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Hprt<tm1(Ins2-HBEGF)Herr>/Y,Tg(Gcg-rtTA)#Herr/0,Tg(tetO-cre)1Jaw/0
  http://metadb.riken.jp/0009179I129X1SvJC57BL6GtROSA26Sortm1EYFPCosGtROSA26SorHprttm1Ins2HBEGFHerrYTgGcgrtTAHerr0TgtetOcre1Jaw0TgtetOcre1JawGtROSA26SorGtROSA26Sortm1EYFPCosHprttm1Ins2HBEGFHerrTgGcgrtTAHerr

class

http://purl.org/net/cito/citesAsAuthority

• Hprt<tm1(Ins2-HBEGF)Herr>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5567081
• Tg(Gcg-HBEGF)#Herr
  http://metadb.riken.jp/db/mgi_rdf/MGI:5567082
• Tg(Gcg-rtTA)#Herr
  http://metadb.riken.jp/db/mgi_rdf/MGI:5567083