abnormal pancreatic beta cell morphology_Irs1<tm1Jos>/Irs1<+>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0

http://metadb.riken.jp/0005217I129S1Sv129X1SvJC57BL6Irs1tm1JosIrs1Irs2tm2MfwIrs2tm2MfwTgIns2cre25Mgn0TgIns2cre25MgnIrs2tm2MfwIrs1Irs1tm1Jos

abnormal pancreatic beta cell morphology_Irs1<tm1Jos>/Irs1<+>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• insulin receptor substrate 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:99454
• insulin receptor substrate 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:109334
• transgene insertion 25, Mark A Magnuson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176225

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Irs1<tm1Jos>/Irs1<+>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Ins2-cre)25Mgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Ins2-cre)25Mgn|Irs2<tm2Mfw>|Irs1<+>|Irs1<tm1Jos>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal pancreatic beta cell morphology
  http://purl.obolibrary.org/obo/MP_0005217

文献

http://purl.org/net/cito/citesAsAuthority

• Xueying. Lin, et.al., Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes., The Journal of clinical investigation, 2004, 114
  http://rdf.ncbi.nlm.nih.gov/pubmed/15467829