impaired glucose tolerance_Irs1<tm1Mfw>/Irs1<+>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0

http://metadb.riken.jp/0005293I129S1Sv129X1SvJC57BL6JDBAFVBNIrs1tm1MfwIrs1Irs2tm2MfwIrs2tm2MfwTgAlbcre21Mgn0Irs2tm2MfwIrs1Irs1tm1MfwTgAlbcre21Mgn

impaired glucose tolerance_Irs1<tm1Mfw>/Irs1<+>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• insulin receptor substrate 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:99454
• insulin receptor substrate 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:109334
• transgene insertion 21, Mark A Magnuson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176226

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Irs1<tm1Mfw>/Irs1<+>,Irs2<tm2Mfw>/Irs2<tm2Mfw>,Tg(Alb-cre)21Mgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Irs2<tm2Mfw>|Irs1<+>|Irs1<tm1Mfw>|Tg(Alb-cre)21Mgn

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• impaired glucose tolerance
  http://purl.obolibrary.org/obo/MP_0005293

文献

http://purl.org/net/cito/citesAsAuthority

• Kyle D. Copps, et.al., Irs1 serine 307 promotes insulin sensitivity in mice., Cell metabolism, 2010, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/20074531