impaired glucose tolerance_Ucp2<tm2.1Lowl>/Ucp2<tm2.1Lowl>,Gt(ROSA)26Sor<tm1(CAG-Kcnj11*,-GFP)Nich>/?,Tg(Pmch-cre)1Lowl/0

http://metadb.riken.jp/0005293I129S4SvJaeSor129S6SvEvTacC57BL6FVBNJUcp2tm21LowlUcp2tm21LowlGtROSA26Sortm1CAGKcnj11GFPNichTgPmchcre1Lowl0GtROSA26Sortm1CAGKcnj11GFPNichUcp2tm21LowlTgPmchcre1Lowl

impaired glucose tolerance_Ucp2<tm2.1Lowl>/Ucp2<tm2.1Lowl>,Gt(ROSA)26Sor<tm1(CAG-Kcnj11*,-GFP)Nich>/?,Tg(Pmch-cre)1Lowl/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• uncoupling protein 2 (mitochondrial, proton carrier)
  http://metadb.riken.jp/db/mgi_rdf/MGI:109354
• transgene insertion 1, Bradford B Lowell
  http://metadb.riken.jp/db/mgi_rdf/MGI:4882133
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ucp2<tm2.1Lowl>/Ucp2<tm2.1Lowl>,Gt(ROSA)26Sor<tm1(CAG-Kcnj11*,-GFP)Nich>/?,Tg(Pmch-cre)1Lowl/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<tm1(CAG-Kcnj11*,-GFP)Nich>|Ucp2<tm2.1Lowl>|Tg(Pmch-cre)1Lowl

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/NJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• impaired glucose tolerance
  http://purl.obolibrary.org/obo/MP_0005293

文献

http://purl.org/net/cito/citesAsAuthority

• Dong. Kong, et.al., Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis., Cell metabolism, 2010, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/21035764