Dong. Kong, et.al., Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis., Cell metabolism, 2010, 12

http://rdf.ncbi.nlm.nih.gov/pubmed/21035764

Dong. Kong, et.al., Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis., Cell metabolism, 2010, 12

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Tg(Pmch-cre)1Lowl
  http://metadb.riken.jp/db/mgi_rdf/MGI:4887235
• Ucp2<tm2.1Lowl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4887236

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased circulating insulin level_Ucp2<tm2.1Lowl>/Ucp2<tm2.1Lowl>,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
  http://metadb.riken.jp/0002727I129S1Sv129S6SvEvTac129X1SvJC57BL6FVBNJUcp2tm21LowlUcp2tm21LowlTgCAGBgeoGFP21Lbe0TgPmchcre1Lowl0Ucp2tm21LowlTgPmchcre1LowlTgCAGBgeoGFP21Lbe
• abnormal single cell response_Gt(ROSA)26Sor<tm1(CAG-Kcnj11*,-GFP)Nich>/?,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
  http://metadb.riken.jp/0003463I129S1Sv129S4SvJaeSor129X1SvJC57BL6FVBNJGtROSA26Sortm1CAGKcnj11GFPNichTgCAGBgeoGFP21Lbe0TgPmchcre1Lowl0TgCAGBgeoGFP21LbeGtROSA26Sortm1CAGKcnj11GFPNichTgPmchcre1Lowl
• impaired glucose tolerance_Gt(ROSA)26Sor<tm1(CAG-Kcnj11*,-GFP)Nich>/?,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
  http://metadb.riken.jp/0005293I129S1Sv129S4SvJaeSor129X1SvJC57BL6FVBNJGtROSA26Sortm1CAGKcnj11GFPNichTgCAGBgeoGFP21Lbe0TgPmchcre1Lowl0TgCAGBgeoGFP21LbeGtROSA26Sortm1CAGKcnj11GFPNichTgPmchcre1Lowl
• decreased circulating glucose level_Ucp2<tm2.1Lowl>/Ucp2<tm2.1Lowl>,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
  http://metadb.riken.jp/0005560I129S1Sv129S6SvEvTac129X1SvJC57BL6FVBNJUcp2tm21LowlUcp2tm21LowlTgCAGBgeoGFP21Lbe0TgPmchcre1Lowl0Ucp2tm21LowlTgPmchcre1LowlTgCAGBgeoGFP21Lbe
• impaired glucose tolerance_Ucp2<tm2.1Lowl>/Ucp2<tm2.1Lowl>,Gt(ROSA)26Sor<tm1(CAG-Kcnj11*,-GFP)Nich>/?,Tg(Pmch-cre)1Lowl/0
  http://metadb.riken.jp/0005293I129S4SvJaeSor129S6SvEvTacC57BL6FVBNJUcp2tm21LowlUcp2tm21LowlGtROSA26Sortm1CAGKcnj11GFPNichTgPmchcre1Lowl0GtROSA26Sortm1CAGKcnj11GFPNichUcp2tm21LowlTgPmchcre1Lowl
• improved glucose tolerance_Ucp2<tm2.1Lowl>/Ucp2<tm2.1Lowl>,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
  http://metadb.riken.jp/0005292I129S1Sv129S6SvEvTac129X1SvJC57BL6FVBNJUcp2tm21LowlUcp2tm21LowlTgCAGBgeoGFP21Lbe0TgPmchcre1Lowl0Ucp2tm21LowlTgPmchcre1LowlTgCAGBgeoGFP21Lbe
• abnormal single cell response_Ucp2<tm2.1Lowl>/Ucp2<tm2.1Lowl>,Tg(CAG-Bgeo/GFP)21Lbe/0,Tg(Pmch-cre)1Lowl/0
  http://metadb.riken.jp/0003463I129S1Sv129S6SvEvTac129X1SvJC57BL6FVBNJUcp2tm21LowlUcp2tm21LowlTgCAGBgeoGFP21Lbe0TgPmchcre1Lowl0Ucp2tm21LowlTgPmchcre1LowlTgCAGBgeoGFP21Lbe

class

http://purl.org/net/cito/citesAsAuthority

• Tg(Pmch-cre)1Lowl
  http://metadb.riken.jp/db/mgi_rdf/MGI:4887235
• Ucp2<tm2.1Lowl>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4887236

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD14108
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD14108
• CD00830
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD00830
• CD02171
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD02171
• CD23914
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD23914