insulin resistance_Lepr<db>/Lepr<db>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Ins2-cre)25Mgn/0

http://metadb.riken.jp/0005331I129S4SvJaeC57BL6C57BLKSJDBALeprdbLeprdbPtentm1HwuPtentm1HwuTgIns2cre25Mgn0Ptentm1HwuTgIns2cre25MgnLeprdb

insulin resistance_Lepr<db>/Lepr<db>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Ins2-cre)25Mgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583
• transgene insertion 25, Mark A Magnuson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176225
• leptin receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:104993

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lepr<db>/Lepr<db>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Ins2-cre)25Mgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pten<tm1Hwu>|Tg(Ins2-cre)25Mgn|Lepr<db>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * C57BLKS/J * DBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• insulin resistance
  http://purl.obolibrary.org/obo/MP_0005331

文献

http://purl.org/net/cito/citesAsAuthority

• Linyuan. Wang, et.al., Deletion of Pten in pancreatic ß-cells protects against deficient ß-cell mass and function in mouse models of type 2 diabetes., Diabetes, 2010, 59
  http://rdf.ncbi.nlm.nih.gov/pubmed/20852026