increased T cell proliferation_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>,Tg(TcraTcrb)425Cbn/0

http://metadb.riken.jp/0005348IBALBcC57BL6Ptpn22tm11KasPtpn22tm11KasTgTcraTcrb425Cbn0TgTcraTcrb425CbnPtpn22tm11Kas

increased T cell proliferation_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>,Tg(TcraTcrb)425Cbn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
  http://metadb.riken.jp/db/mgi_rdf/MGI:107170
• transgene insertion 425, Frank Carbone
  http://metadb.riken.jp/db/mgi_rdf/MGI:3046085

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>,Tg(TcraTcrb)425Cbn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(TcraTcrb)425Cbn|Ptpn22<tm1.1Kas>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: BALB/c * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased T cell proliferation
  http://purl.obolibrary.org/obo/MP_0005348

文献

http://purl.org/net/cito/citesAsAuthority

• Jinyi. Zhang, et.al., The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness., Nature genetics, 2011, 43
  http://rdf.ncbi.nlm.nih.gov/pubmed/21841778