Jinyi. Zhang, et.al., The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness., Nature genetics, 2011, 43

http://rdf.ncbi.nlm.nih.gov/pubmed/21841778

Jinyi. Zhang, et.al., The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness., Nature genetics, 2011, 43

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5294241

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased spleen germinal center size_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/0008483IC57BL6Ptpn22tm11KasPtpn22tm11KasPtpn22tm11Kas
• increased T cell number_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/0005015IC57BL6Ptpn22tm11KasPtpn22tm11KasPtpn22tm11Kas
• enlarged spleen_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/0000691IC57BL6Ptpn22tm11KasPtpn22tm11KasPtpn22tm11Kas
• increased B cell proliferation_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/0005154IC57BL6Ptpn22tm11KasPtpn22tm11KasPtpn22tm11Kas
• enlarged thymus_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/0000709IC57BL6Ptpn22tm11KasPtpn22tm11KasPtpn22tm11Kas
• abnormal dendritic cell physiology_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/0002376IC57BL6Ptpn22tm11KasPtpn22tm11KasPtpn22tm11Kas
• increased spleen germinal center number_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/0008481IC57BL6Ptpn22tm11KasPtpn22tm11KasPtpn22tm11Kas
• increased IgM level_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/0002494IC57BL6Ptpn22tm11KasPtpn22tm11KasPtpn22tm11Kas
• increased T cell proliferation_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/0005348IC57BL6Ptpn22tm11KasPtpn22tm11KasPtpn22tm11Kas
• increased interleukin-12 secretion_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/0008663IC57BL6Ptpn22tm11KasPtpn22tm11KasPtpn22tm11Kas
• increased IgG2a level_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/0008500IC57BL6Ptpn22tm11KasPtpn22tm11KasPtpn22tm11Kas
• increased T cell proliferation_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>,Tg(TcraTcrb)425Cbn/0
  http://metadb.riken.jp/0005348IBALBcC57BL6Ptpn22tm11KasPtpn22tm11KasTgTcraTcrb425Cbn0TgTcraTcrb425CbnPtpn22tm11Kas
• increased CD4-positive, alpha beta T cell number_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/0008074IC57BL6Ptpn22tm11KasPtpn22tm11KasPtpn22tm11Kas
• increased CD4-positive, alpha beta T cell number_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>,Tg(TcraTcrb)425Cbn/0
  http://metadb.riken.jp/0008074IBALBcC57BL6Ptpn22tm11KasPtpn22tm11KasTgTcraTcrb425Cbn0TgTcraTcrb425CbnPtpn22tm11Kas
• increased CD8-positive, alpha-beta T cell number_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/0008078IC57BL6Ptpn22tm11KasPtpn22tm11KasPtpn22tm11Kas
• increased IgG3 level_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/0008502IC57BL6Ptpn22tm11KasPtpn22tm11KasPtpn22tm11Kas
• increased dendritic cell number_Ptpn22<tm1.1Kas>/Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/0008126IC57BL6Ptpn22tm11KasPtpn22tm11KasPtpn22tm11Kas

class

http://purl.org/net/cito/citesAsAuthority

• Ptpn22<tm1.1Kas>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5294241