increased chronic myelocytic leukemia incidence_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0

http://metadb.riken.jp/0005481I129P2OlaHsdC57BL6CBAJDBA2FVBNGtROSA26Sortm4CAGhsb5NkiGtROSA26SorTgMx1cre1Cgn0TgTal1tTA19Dgt0TgtetOBCRABL12Dgt0TgTnpbsbGrOncaGsva0TgTnpbsbGrOncaGsvaTgTal1tTA19DgtGtROSA26SorTgtetOBCRABL12DgtTgMx1cre1CgnGtROSA26Sortm4CAGhsb5Nki

increased chronic myelocytic leukemia incidence_Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 2, Daniel G Tenen
  http://metadb.riken.jp/db/mgi_rdf/MGI:3621056
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgenic transposon concatemer #a, George S Vassiliou
  http://metadb.riken.jp/db/mgi_rdf/MGI:5004899
• transgene insertion 19, Daniel G Tenen
  http://metadb.riken.jp/db/mgi_rdf/MGI:3693323
• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>/Gt(ROSA)26Sor<+>,Tg(Mx1-cre)1Cgn/0,Tg(Tal1-tTA)19Dgt/0,Tg(tetO-BCR/ABL1)2Dgt/0,TgTn(pb-sb-GrOnc)#aGsva/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• TgTn(pb-sb-GrOnc)#aGsva|Tg(Tal1-tTA)19Dgt|Gt(ROSA)26Sor<+>|Tg(tetO-BCR/ABL1)2Dgt|Tg(Mx1-cre)1Cgn|Gt(ROSA)26Sor<tm4(CAG-hsb5)Nki>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * CBA/J * DBA/2 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased chronic myelocytic leukemia incidence
  http://purl.obolibrary.org/obo/MP_0005481

文献

http://purl.org/net/cito/citesAsAuthority

• George. Giotopoulos, et.al., A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression., The Journal of experimental medicine, 2015, 212
  http://rdf.ncbi.nlm.nih.gov/pubmed/26304963