decreased circulating glucose level_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>,Trp53<tm1Brd>/Trp53<tm1Brd>

http://metadb.riken.jp/0005560I129S6SvEvTac129S7SvEvBrdFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdTrp53tm1BrdTrp53tm1BrdSirt6tm22CxdTrp53tm1Brd

decreased circulating glucose level_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>,Trp53<tm1Brd>/Trp53<tm1Brd>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• sirtuin 6
  http://metadb.riken.jp/db/mgi_rdf/MGI:1354161
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>,Trp53<tm1Brd>/Trp53<tm1Brd>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Sirt6<tm2.2Cxd>|Trp53<tm1Brd>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N * NIH Black Swiss

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased circulating glucose level
  http://purl.obolibrary.org/obo/MP_0005560

文献

http://purl.org/net/cito/citesAsAuthority

• Cuiying. Xiao, et.al., SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20847051