Cuiying. Xiao, et.al., SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice., The Journal of biological chemistry, 2010, 285

http://rdf.ncbi.nlm.nih.gov/pubmed/20847051

Cuiying. Xiao, et.al., SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice., The Journal of biological chemistry, 2010, 285

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4867398
• Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4867399

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased bone mineral density_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0000063I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• decreased bone mineral density_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0000063I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• malocclusion_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0000120I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• malocclusion_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0000120I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• kyphosis_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0000160I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• kyphosis_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0000160I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
他41件を見る
• lordosis_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0000162I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• lordosis_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0000162I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• hypoglycemia_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0000189I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• hypoglycemia_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0000189I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• decreased body weight_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0001262I129S6SvEvTac129S7SvEvBrdFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdTrp53tm1BrdTrp53tm1BrdSirt6tm22CxdTrp53tm1Brd
• decreased body weight_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0001262I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• decreased body weight_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0001262I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• decreased body size_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0001265I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• decreased body size_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0001265I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• abnormal nursing_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0001382I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• abnormal nursing_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0001382I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• reduced female fertility_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0001923I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• reduced female fertility_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0001923I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• male infertility_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0001925I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• male infertility_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0001925I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• abnormal glucose homeostasis_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0002078I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• abnormal glucose homeostasis_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0002078I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• premature death_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0002083I129S6SvEvTac129S7SvEvBrdFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdTrp53tm1BrdTrp53tm1BrdSirt6tm22CxdTrp53tm1Brd
• premature death_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0002083I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• premature death_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0002083I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• abnormal eye morphology_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0002092I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• abnormal eye morphology_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0002092I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• decreased circulating insulin level_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0002727I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• decreased circulating insulin level_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0002727I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• increased insulin sensitivity_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0002891I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• increased insulin sensitivity_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0002891I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• premature aging_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0003786I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• premature aging_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0003786I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• narrow eye opening_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0005287I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• narrow eye opening_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0005287I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• decreased circulating glucose level_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>,Trp53<tm1Brd>/Trp53<tm1Brd>
  http://metadb.riken.jp/0005560I129S6SvEvTac129S7SvEvBrdFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdTrp53tm1BrdTrp53tm1BrdSirt6tm22CxdTrp53tm1Brd
• decreased circulating glucose level_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0005560I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• decreased circulating glucose level_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0005560I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• early cellular replicative senescence_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0008008I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• early cellular replicative senescence_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0008008I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• abnormal spleen physiology_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0008737I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• abnormal spleen physiology_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0008737I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• decreased subcutaneous adipose tissue amount_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0008844I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• decreased subcutaneous adipose tissue amount_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0008844I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd
• decreased total body fat amount_Sirt6<tm2.2Cxd>/Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/0010025I129S6SvEvTacFVBNNIHBlackSwissSirt6tm22CxdSirt6tm22CxdSirt6tm22Cxd
• decreased total body fat amount_Sirt6<tm2.1Cxd>/Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/0010025I129S6SvEvTacNIHBlackSwissSirt6tm21CxdSirt6tm21CxdSirt6tm21Cxd

class

http://purl.org/net/cito/citesAsAuthority

• Sirt6<tm2.2Cxd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4867398
• Sirt6<tm2.1Cxd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4867399

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD24116
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD24116