decreased ventricle muscle contractility_Tg(Myh6-Nox4)#Jusa/0

http://metadb.riken.jp/0005598FVBTgMyh6Nox4JusaTgMyh6Nox4Jusa0TgMyh6Nox4Jusa

decreased ventricle muscle contractility_Tg(Myh6-Nox4)#Jusa/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion, Junichi Sadoshima
  http://metadb.riken.jp/db/mgi_rdf/MGI:4834493

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tg(Myh6-Nox4)#Jusa/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Myh6-Nox4)#Jusa

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• FVB-Tg(Myh6-Nox4)#Jusa

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased ventricle muscle contractility
  http://purl.obolibrary.org/obo/MP_0005598

文献

http://purl.org/net/cito/citesAsAuthority

• Junya. Kuroda, et.al., NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107
  http://rdf.ncbi.nlm.nih.gov/pubmed/20713697
• Tetsuro. Ago, et.al., Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes., Circulation research, 2010, 106
  http://rdf.ncbi.nlm.nih.gov/pubmed/20185797