abnormal mitochondrion morphology_Park2<tm1Shn>/Park2<tm1Shn>,Slc6a3<tm4.1(tTA)Xz>/?,Tg(tetO-SNCA*A53T)E2Cai/?

http://metadb.riken.jp/0006035I129S4SvJaeSor129S6SvEvTacC57BL6Park2tm1ShnPark2tm1ShnSlc6a3tm41tTAXzTgtetOSNCAA53TE2CaiPark2tm1ShnSlc6a3tm41tTAXzTgtetOSNCAA53TE2Cai

abnormal mitochondrion morphology_Park2<tm1Shn>/Park2<tm1Shn>,Slc6a3<tm4.1(tTA)Xz>/?,Tg(tetO-SNCA*A53T)E2Cai/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:94862
• transgene insertion E2, Huaibin Cai
  http://metadb.riken.jp/db/mgi_rdf/MGI:4420800
• Parkinson disease (autosomal recessive, juvenile) 2, parkin
  http://metadb.riken.jp/db/mgi_rdf/MGI:1355296

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Park2<tm1Shn>/Park2<tm1Shn>,Slc6a3<tm4.1(tTA)Xz>/?,Tg(tetO-SNCA*A53T)E2Cai/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Park2<tm1Shn>|Slc6a3<tm4.1(tTA)Xz>|Tg(tetO-SNCA*A53T)E2Cai

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal mitochondrion morphology
  http://purl.obolibrary.org/obo/MP_0006035

文献

http://purl.org/net/cito/citesAsAuthority

• Linan. Chen, et.al., A53T human α-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, 35
  http://rdf.ncbi.nlm.nih.gov/pubmed/25609609