abnormal sinoatrial node conduction_Hcn4<tm1.1Ggc>/Hcn4<tm1.1Ggc>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0

http://metadb.riken.jp/0006142I129SSvEvC57BL6FVBNHcn4tm11GgcHcn4tm11GgcA1cfTgMyh6creEsr11Jmk0Hcn4tm11GgcA1cfTgMyh6creEsr11Jmk

abnormal sinoatrial node conduction_Hcn4<tm1.1Ggc>/Hcn4<tm1.1Ggc>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• hyperpolarization-activated, cyclic nucleotide-gated K+ 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:1298209
• APOBEC1 complementation factor
  http://metadb.riken.jp/db/mgi_rdf/MGI:1917115

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Hcn4<tm1.1Ggc>/Hcn4<tm1.1Ggc>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Hcn4<tm1.1Ggc>|A1cf<Tg(Myh6-cre/Esr1*)1Jmk>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S/SvEv * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal sinoatrial node conduction
  http://purl.obolibrary.org/obo/MP_0006142

文献

http://purl.org/net/cito/citesAsAuthority

• Mirko. Baruscotti, et.al., Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21220308