increased medulloblastoma incidence_Brca2<tm1Brn>/Brca2<tm1Brn>,Ptch1<tm1Mps>/Ptch1<+>,Trp53<tm1Tyj>/Trp53<+>,Tg(Nes-cre)1Kln/0

http://metadb.riken.jp/0006283I129C57BL6SJLBrca2tm1BrnBrca2tm1BrnPtch1tm1MpsPtch1Trp53tm1TyjTrp53TgNescre1Kln0Ptch1tm1MpsPtch1TgNescre1KlnTrp53Trp53tm1TyjBrca2tm1Brn

increased medulloblastoma incidence_Brca2<tm1Brn>/Brca2<tm1Brn>,Ptch1<tm1Mps>/Ptch1<+>,Trp53<tm1Tyj>/Trp53<+>,Tg(Nes-cre)1Kln/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• breast cancer 2, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:109337
• patched 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:105373
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 1, Rudiger Klein
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176172

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca2<tm1Brn>/Brca2<tm1Brn>,Ptch1<tm1Mps>/Ptch1<+>,Trp53<tm1Tyj>/Trp53<+>,Tg(Nes-cre)1Kln/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptch1<tm1Mps>|Ptch1<+>|Tg(Nes-cre)1Kln|Trp53<+>|Trp53<tm1Tyj>|Brca2<tm1Brn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased medulloblastoma incidence
  http://purl.obolibrary.org/obo/MP_0006283

文献

http://purl.org/net/cito/citesAsAuthority

• Pierre-Olivier. Frappart, et.al., Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106
  http://rdf.ncbi.nlm.nih.gov/pubmed/19164512