early cellular replicative senescence_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<tm1.1Rdp>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>

http://metadb.riken.jp/0008008I129P2OlaHsd129S4SvJaeC57BL6Hdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2tm11RdpGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnHdac1tm1IcsHdac2tm11RdpGtROSA26Sor

early cellular replicative senescence_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<tm1.1Rdp>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• histone deacetylase 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:1097691
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• histone deacetylase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:108086

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<tm1.1Rdp>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>|Hdac1<tm1Ics>|Hdac2<tm1.1Rdp>|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• early cellular replicative senescence
  http://purl.obolibrary.org/obo/MP_0008008

文献

http://purl.org/net/cito/citesAsAuthority

• Roel H. Wilting, et.al., Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis., The EMBO journal, 2010, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/20571512