Roel H. Wilting, et.al., Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis., The EMBO journal, 2010, 29

http://rdf.ncbi.nlm.nih.gov/pubmed/20571512

Roel H. Wilting, et.al., Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis., The EMBO journal, 2010, 29

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Hdac1<tm1Ics>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5494616

class

http://purl.org/net/cito/citesAsAuthority

• Hdac1<tm1Ics>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5494616

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased bone marrow cell number_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000333I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2TgMx1cre1Cgn0Hdac2Hdac2tm11RdpHdac1tm1IcsTgMx1cre1Cgn
• decreased bone marrow cell number_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<tm1.1Rdp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000333I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2tm11RdpTgMx1cre1Cgn0TgMx1cre1CgnHdac1tm1IcsHdac2tm11Rdp
• anemia_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001577I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2TgMx1cre1Cgn0Hdac2Hdac2tm11RdpHdac1tm1IcsTgMx1cre1Cgn
• anemia_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<tm1.1Rdp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001577I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2tm11RdpTgMx1cre1Cgn0TgMx1cre1CgnHdac1tm1IcsHdac2tm11Rdp
• internal hemorrhage_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<tm1.1Rdp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001634I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2tm11RdpTgMx1cre1Cgn0TgMx1cre1CgnHdac1tm1IcsHdac2tm11Rdp
• premature death_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<tm1.1Rdp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2tm11RdpTgMx1cre1Cgn0TgMx1cre1CgnHdac1tm1IcsHdac2tm11Rdp
他16件を見る
• abnormal megakaryocyte morphology_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002417I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2TgMx1cre1Cgn0Hdac2Hdac2tm11RdpHdac1tm1IcsTgMx1cre1Cgn
• decreased erythrocyte cell number_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002875I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2TgMx1cre1Cgn0Hdac2Hdac2tm11RdpHdac1tm1IcsTgMx1cre1Cgn
• decreased erythrocyte cell number_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<tm1.1Rdp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002875I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2tm11RdpTgMx1cre1Cgn0TgMx1cre1CgnHdac1tm1IcsHdac2tm11Rdp
• thrombocytopenia_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003179I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2TgMx1cre1Cgn0Hdac2Hdac2tm11RdpHdac1tm1IcsTgMx1cre1Cgn
• thrombocytopenia_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<tm1.1Rdp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0003179I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2tm11RdpTgMx1cre1Cgn0TgMx1cre1CgnHdac1tm1IcsHdac2tm11Rdp
• abnormal mitosis_Cdkn2a<tm2.1Brn>/Cdkn2a<tm2.1Brn>,Hdac2<tm1.2Rdp>/Hdac2<tm1.2Rdp>
  http://metadb.riken.jp/0004046I129P2OlaHsd129S4SvJaeC57BL6Cdkn2atm21BrnCdkn2atm21BrnHdac2tm12RdpHdac2tm12RdpHdac2tm12RdpCdkn2atm21Brn
• abnormal mitosis_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<tm1.1Rdp>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0004046I129P2OlaHsd129S4SvJaeC57BL6Hdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2tm11RdpGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnHdac1tm1IcsHdac2tm11RdpGtROSA26Sor
• abnormal mitosis_Cdkn1a<tm1Led>/Cdkn1a<tm1Led>,Hdac2<tm1.2Rdp>/Hdac2<tm1.2Rdp>
  http://metadb.riken.jp/0004046I129S4SvJae129S6SvEvTacC57BL6Cdkn1atm1LedCdkn1atm1LedHdac2tm12RdpHdac2tm12RdpCdkn1atm1LedHdac2tm12Rdp
• lethargy_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005202I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2TgMx1cre1Cgn0Hdac2Hdac2tm11RdpHdac1tm1IcsTgMx1cre1Cgn
• lethargy_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<tm1.1Rdp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005202I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2tm11RdpTgMx1cre1Cgn0TgMx1cre1CgnHdac1tm1IcsHdac2tm11Rdp
• increased apoptosis_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<tm1.1Rdp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0006042I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2tm11RdpTgMx1cre1Cgn0TgMx1cre1CgnHdac1tm1IcsHdac2tm11Rdp
• early cellular replicative senescence_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<tm1.1Rdp>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0008008I129P2OlaHsd129S4SvJaeC57BL6Hdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2tm11RdpGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnHdac1tm1IcsHdac2tm11RdpGtROSA26Sor
• early cellular replicative senescence_Cdkn1a<tm1Led>/Cdkn1a<tm1Led>,Hdac2<tm1.2Rdp>/Hdac2<tm1.2Rdp>
  http://metadb.riken.jp/0008008I129S4SvJae129S6SvEvTacC57BL6Cdkn1atm1LedCdkn1atm1LedHdac2tm12RdpHdac2tm12RdpCdkn1atm1LedHdac2tm12Rdp
• decreased megakaryocyte cell number_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008255I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2TgMx1cre1Cgn0Hdac2Hdac2tm11RdpHdac1tm1IcsTgMx1cre1Cgn
• decreased megakaryocyte cell number_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<tm1.1Rdp>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008255I129S4SvJaeC57BL6CBAHdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2tm11RdpTgMx1cre1Cgn0TgMx1cre1CgnHdac1tm1IcsHdac2tm11Rdp
• decreased fibroblast proliferation_Hdac1<tm1Ics>/Hdac1<tm1Ics>,Hdac2<tm1.1Rdp>/Hdac2<tm1.1Rdp>,Gt(ROSA)26Sor<tm2(cre/ERT2)Brn>/Gt(ROSA)26Sor<+>
  http://metadb.riken.jp/0011704I129P2OlaHsd129S4SvJaeC57BL6Hdac1tm1IcsHdac1tm1IcsHdac2tm11RdpHdac2tm11RdpGtROSA26Sortm2creERT2BrnGtROSA26SorGtROSA26Sortm2creERT2BrnHdac1tm1IcsHdac2tm11RdpGtROSA26Sor