early cellular replicative senescence_Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>

http://metadb.riken.jp/0008008I129S4SvJaeC57BL6Col1a1tm11tetORFPRNAiRpa3SloweCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorGtROSA26Sortm1rtTAM2JaeCol1a1GtROSA26SorCol1a1tm11tetORFPRNAiRpa3Slowe

early cellular replicative senescence_Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• collagen, type I, alpha 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88467

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>|Col1a1<+>|Gt(ROSA)26Sor<+>|Col1a1<tm11(tetO*-RFP/RNAi:Rpa3)Slowe>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• early cellular replicative senescence
  http://purl.obolibrary.org/obo/MP_0008008

文献

http://purl.org/net/cito/citesAsAuthority

• Katherine. McJunkin, et.al., Reversible suppression of an essential gene in adult mice using transgenic RNA interference., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21482754