early cellular replicative senescence_Kdm5a<tm1Kael>/Kdm5a<tm1Kael>,Tg(CAG-cre/Esr1*)5Amc/0

http://metadb.riken.jp/0008008I129S6SvEvTacC57BL6CBAKdm5atm1KaelKdm5atm1KaelTgCAGcreEsr15Amc0TgCAGcreEsr15AmcKdm5atm1Kael

early cellular replicative senescence_Kdm5a<tm1Kael>/Kdm5a<tm1Kael>,Tg(CAG-cre/Esr1*)5Amc/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 5, Andrew P McMahon
  http://metadb.riken.jp/db/mgi_rdf/MGI:2182765
• lysine (K)-specific demethylase 5A
  http://metadb.riken.jp/db/mgi_rdf/MGI:2136980

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kdm5a<tm1Kael>/Kdm5a<tm1Kael>,Tg(CAG-cre/Esr1*)5Amc/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(CAG-cre/Esr1*)5Amc|Kdm5a<tm1Kael>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• early cellular replicative senescence
  http://purl.obolibrary.org/obo/MP_0008008

文献

http://purl.org/net/cito/citesAsAuthority

• Wenchu. Lin, et.al., Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21788502