Wenchu. Lin, et.al., Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108

http://rdf.ncbi.nlm.nih.gov/pubmed/21788502

Wenchu. Lin, et.al., Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal cell differentiation_Rb1<tm1Tyj>/Rb1<tm1Tyj>
  http://metadb.riken.jp/0005076I129S2SvPas129S6SvEvTacFVBNRb1tm1TyjRb1tm1TyjRb1tm1Tyj
• premature death_Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0002083I129S2SvPas129S6SvEvTacFVBNRb1tm1TyjRb1Rb1Rb1tm1Tyj
• early cellular replicative senescence_Kdm5a<tm1Kael>/Kdm5a<tm1Kael>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0008008I129S6SvEvTacC57BL6CBAKdm5atm1KaelKdm5atm1KaelTgCAGcreEsr15Amc0TgCAGcreEsr15AmcKdm5atm1Kael
• increased thyroid tumor incidence_Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0010316I129S2SvPas129S6SvEvTacFVBNRb1tm1TyjRb1Rb1Rb1tm1Tyj
• increased fibroblast proliferation_Kdm5a<tm1.1Kael>/Kdm5a<+>,Rb1<tm1Tyj>/Rb1<tm1Tyj>
  http://metadb.riken.jp/0011703I129S2SvPas129S6SvEvTacFVBNKdm5atm11KaelKdm5aRb1tm1TyjRb1tm1TyjKdm5atm11KaelRb1tm1TyjKdm5a
• increased pituitary gland tumor incidence_Kdm5a<tm1.1Kael>/Kdm5a<+>,Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0010320I129S2SvPas129S6SvEvTacFVBNKdm5atm11KaelKdm5aRb1tm1TyjRb1Kdm5aRb1tm1TyjKdm5atm11KaelRb1
• increased pituitary gland tumor incidence_Kdm5a<tm1.1Kael>/Kdm5a<tm1.1Kael>,Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0010320I129S2SvPas129S6SvEvTacFVBNKdm5atm11KaelKdm5atm11KaelRb1tm1TyjRb1Rb1tm1TyjRb1Kdm5atm11Kael
• premature death_Kdm5a<tm1.1Kael>/Kdm5a<tm1.1Kael>,Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0002083I129S2SvPas129S6SvEvTacFVBNKdm5atm11KaelKdm5atm11KaelRb1tm1TyjRb1Rb1tm1TyjRb1Kdm5atm11Kael
• increased thyroid tumor incidence_Kdm5a<tm1.1Kael>/Kdm5a<+>,Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0010316I129S2SvPas129S6SvEvTacFVBNKdm5atm11KaelKdm5aRb1tm1TyjRb1Kdm5aRb1tm1TyjKdm5atm11KaelRb1
• increased insulinoma incidence_Kdm5a<tm1Kael>/Kdm5a<tm1Kael>,Men1<tm2.1Mmey>/Men1<tm2.1Mmey>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0003364I129S6SvEvTacC57BL6CBAJFVBNKdm5atm1KaelKdm5atm1KaelMen1tm21MmeyMen1tm21MmeyTgIns2cre23Herr0Kdm5atm1KaelTgIns2cre23HerrMen1tm21Mmey
• increased thyroid tumor incidence_Kdm5a<tm1.1Kael>/Kdm5a<tm1.1Kael>,Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0010316I129S2SvPas129S6SvEvTacFVBNKdm5atm11KaelKdm5atm11KaelRb1tm1TyjRb1Rb1tm1TyjRb1Kdm5atm11Kael
• abnormal pancreatic islet morphology_Men1<tm2.1Mmey>/Men1<tm2.1Mmey>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0005215I129S6SvEvTacC57BL6CBAJFVBNMen1tm21MmeyMen1tm21MmeyTgIns2cre23Herr0Men1tm21MmeyTgIns2cre23Herr
• early cellular replicative senescence_Kdm5a<tm1.1Kael>/Kdm5a<tm1.1Kael>
  http://metadb.riken.jp/0008008I129S6SvEvTacFVBNKdm5atm11KaelKdm5atm11KaelKdm5atm11Kael
• abnormal cell differentiation_Kdm5a<tm1.1Kael>/Kdm5a<tm1.1Kael>,Rb1<tm1Tyj>/Rb1<tm1Tyj>
  http://metadb.riken.jp/0005076I129S2SvPas129S6SvEvTacFVBNKdm5atm11KaelKdm5atm11KaelRb1tm1TyjRb1tm1TyjKdm5atm11KaelRb1tm1Tyj
• embryonic lethality, complete penetrance_Kdm5a<tm1.1Kael>/Kdm5a<tm1.1Kael>,Rb1<tm1Tyj>/Rb1<tm1Tyj>
  http://metadb.riken.jp/0011092I129S2SvPas129S6SvEvTacFVBNKdm5atm11KaelKdm5atm11KaelRb1tm1TyjRb1tm1TyjKdm5atm11KaelRb1tm1Tyj
• increased pituitary gland tumor incidence_Rb1<tm1Tyj>/Rb1<+>
  http://metadb.riken.jp/0010320I129S2SvPas129S6SvEvTacFVBNRb1tm1TyjRb1Rb1Rb1tm1Tyj
• embryonic lethality, complete penetrance_Rb1<tm1Tyj>/Rb1<tm1Tyj>
  http://metadb.riken.jp/0011092I129S2SvPas129S6SvEvTacFVBNRb1tm1TyjRb1tm1TyjRb1tm1Tyj
• pancreatic islet hyperplasia_Men1<tm2.1Mmey>/Men1<tm2.1Mmey>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0005491I129S6SvEvTacC57BL6CBAJFVBNMen1tm21MmeyMen1tm21MmeyTgIns2cre23Herr0Men1tm21MmeyTgIns2cre23Herr
• increased insulinoma incidence_Men1<tm2.1Mmey>/Men1<tm2.1Mmey>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0003364I129S6SvEvTacC57BL6CBAJFVBNMen1tm21MmeyMen1tm21MmeyTgIns2cre23Herr0Men1tm21MmeyTgIns2cre23Herr
• abnormal pancreatic islet morphology_Kdm5a<tm1Kael>/Kdm5a<tm1Kael>,Men1<tm2.1Mmey>/Men1<tm2.1Mmey>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0005215I129S6SvEvTacC57BL6CBAJFVBNKdm5atm1KaelKdm5atm1KaelMen1tm21MmeyMen1tm21MmeyTgIns2cre23Herr0Kdm5atm1KaelTgIns2cre23HerrMen1tm21Mmey
• abnormal pancreas physiology_Men1<tm2.1Mmey>/Men1<tm2.1Mmey>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002693I129S6SvEvTacC57BL6CBAJFVBNMen1tm21MmeyMen1tm21MmeyTgIns2cre23Herr0Men1tm21MmeyTgIns2cre23Herr
• pancreatic islet hyperplasia_Kdm5a<tm1Kael>/Kdm5a<tm1Kael>,Men1<tm2.1Mmey>/Men1<tm2.1Mmey>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0005491I129S6SvEvTacC57BL6CBAJFVBNKdm5atm1KaelKdm5atm1KaelMen1tm21MmeyMen1tm21MmeyTgIns2cre23Herr0Kdm5atm1KaelTgIns2cre23HerrMen1tm21Mmey
• early cellular replicative senescence_Kdm5a<tm1Kael>/Kdm5a<tm1Kael>
  http://metadb.riken.jp/0008008I129S6SvEvTacC57BL6CBAKdm5atm1KaelKdm5atm1KaelKdm5atm1Kael
• embryonic lethality, complete penetrance_Kdm5a<tm1.1Kael>/Kdm5a<+>,Rb1<tm1Tyj>/Rb1<tm1Tyj>
  http://metadb.riken.jp/0011092I129S2SvPas129S6SvEvTacFVBNKdm5atm11KaelKdm5aRb1tm1TyjRb1tm1TyjKdm5atm11KaelRb1tm1TyjKdm5a
• premature death_Kdm5a<tm1Kael>/Kdm5a<tm1Kael>,Men1<tm2.1Mmey>/Men1<tm2.1Mmey>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002083I129S6SvEvTacC57BL6CBAJFVBNKdm5atm1KaelKdm5atm1KaelMen1tm21MmeyMen1tm21MmeyTgIns2cre23Herr0Kdm5atm1KaelTgIns2cre23HerrMen1tm21Mmey
• premature death_Men1<tm2.1Mmey>/Men1<tm2.1Mmey>,Tg(Ins2-cre)23Herr/0
  http://metadb.riken.jp/0002083I129S6SvEvTacC57BL6CBAJFVBNMen1tm21MmeyMen1tm21MmeyTgIns2cre23Herr0Men1tm21MmeyTgIns2cre23Herr