increased lung tumor incidence_Kras<tm4Tyj>/Kras<+>,Map2k7<tm1.1Twad>/Map2k7<tm1.2Twad>,Trp53<tm1Tyj>/Trp53<tm1Tyj>

http://metadb.riken.jp/0008014I129P2OlaHsd129S2SvPas129S4SvJaeC57BL6Krastm4TyjKrasMap2k7tm11TwadMap2k7tm12TwadTrp53tm1TyjTrp53tm1TyjKrastm4TyjKrasMap2k7tm11TwadTrp53tm1TyjMap2k7tm12Twad

increased lung tumor incidence_Kras<tm4Tyj>/Kras<+>,Map2k7<tm1.1Twad>/Map2k7<tm1.2Twad>,Trp53<tm1Tyj>/Trp53<tm1Tyj>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• mitogen-activated protein kinase kinase 7
  http://metadb.riken.jp/db/mgi_rdf/MGI:1346871
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Map2k7<tm1.1Twad>/Map2k7<tm1.2Twad>,Trp53<tm1Tyj>/Trp53<tm1Tyj>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kras<tm4Tyj>|Kras<+>|Map2k7<tm1.1Twad>|Trp53<tm1Tyj>|Map2k7<tm1.2Twad>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased lung tumor incidence
  http://purl.obolibrary.org/obo/MP_0008014

文献

http://purl.org/net/cito/citesAsAuthority

• Daniel. Schramek, et.al., The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression., Nature genetics, 2011, 43
  http://rdf.ncbi.nlm.nih.gov/pubmed/21317887