Daniel. Schramek, et.al., The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression., Nature genetics, 2011, 43

http://rdf.ncbi.nlm.nih.gov/pubmed/21317887

Daniel. Schramek, et.al., The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression., Nature genetics, 2011, 43

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Map2k7<tm1.1Twad>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4948950
• Map2k7<tm1.2Twad>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4948951

class

http://purl.org/net/cito/citesAsAuthority

• Map2k7<tm1.1Twad>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4948950
• Map2k7<tm1.2Twad>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4948951

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• eyelids open at birth_Map2k7<tm1.1Twad>/Map2k7<tm1.1Twad>,Tg(KRT5-cre)1Tak/0
  http://metadb.riken.jp/0001302I129P2OlaHsdC3HC57BL6Map2k7tm11TwadMap2k7tm11TwadTgKRT5cre1Tak0Map2k7tm11TwadTgKRT5cre1Tak
• increased lung tumor incidence_Kras<tm4Tyj>/Kras<+>,Mapk8<tm1Wag>/Mapk8<+>,Mapk9<tm1Mka>/Mapk9<tm1Mka>
  http://metadb.riken.jp/0008014I129Sv129P2OlaHsd129S4SvJaeC57BL6Krastm4TyjKrasMapk8tm1WagMapk8Mapk9tm1MkaMapk9tm1MkaMapk8tm1WagMapk8KrasKrastm4TyjMapk9tm1Mka
• increased lung tumor incidence_Kras<tm4Tyj>/Kras<+>,Map2k7<tm1.1Twad>/Map2k7<tm1.2Twad>
  http://metadb.riken.jp/0008014B6CgKrastm4TyjMap2k7tm11TwadMap2k7tm12TwadKrastm4TyjKrasMap2k7tm11TwadMap2k7tm12TwadKrasKrastm4TyjMap2k7tm11TwadMap2k7tm12Twad
• premature death_Map2k7<tm1.1Twad>/Map2k7<tm1.2Twad>,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
  http://metadb.riken.jp/0002083I129P2OlaHsdC57BL6CD1DBAFVBNMap2k7tm11TwadMap2k7tm12TwadTgMMTVcre4Mam0TgMMTVErbb21Pv0TgMMTVErbb21PvMap2k7tm11TwadTgMMTVcre4MamMap2k7tm12Twad
• abnormal DNA repair_Kras<tm4Tyj>/Kras<+>,Map2k7<tm1.1Twad>/Map2k7<tm1.2Twad>
  http://metadb.riken.jp/0008058B6CgKrastm4TyjMap2k7tm11TwadMap2k7tm12TwadKrastm4TyjKrasMap2k7tm11TwadMap2k7tm12TwadKrasKrastm4TyjMap2k7tm11TwadMap2k7tm12Twad
• increased mammary adenocarcinoma incidence_Map2k7<tm1.1Twad>/Map2k7<tm1.2Twad>,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
  http://metadb.riken.jp/0001883I129P2OlaHsdC57BL6CD1DBAFVBNMap2k7tm11TwadMap2k7tm12TwadTgMMTVcre4Mam0TgMMTVErbb21Pv0TgMMTVErbb21PvMap2k7tm11TwadTgMMTVcre4MamMap2k7tm12Twad
• premature death_Kras<tm4Tyj>/Kras<+>,Map2k7<tm1.1Twad>/Map2k7<tm1.2Twad>
  http://metadb.riken.jp/0002083B6CgKrastm4TyjMap2k7tm11TwadMap2k7tm12TwadKrastm4TyjKrasMap2k7tm11TwadMap2k7tm12TwadKrasKrastm4TyjMap2k7tm11TwadMap2k7tm12Twad
• abnormal eyelid morphology_Mapk8<tm1Wag>/Mapk8<tm1Wag>,Mapk9<tm1Mka>/Mapk9<+>
  http://metadb.riken.jp/0001340I129Sv129P2OlaHsdMapk8tm1WagMapk8tm1WagMapk9tm1MkaMapk9Mapk9Mapk9tm1MkaMapk8tm1Wag
• increased lung tumor incidence_Kras<tm4Tyj>/Kras<+>,Map2k7<tm1.1Twad>/Map2k7<tm1.2Twad>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0008014I129P2OlaHsd129S2SvPas129S4SvJaeC57BL6Krastm4TyjKrasMap2k7tm11TwadMap2k7tm12TwadTrp53tm1TyjTrp53tm1TyjKrastm4TyjKrasMap2k7tm11TwadTrp53tm1TyjMap2k7tm12Twad
• increased lung adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Map2k7<tm1.1Twad>/Map2k7<tm1.2Twad>,Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002027I129P2OlaHsd129S2SvPas129S4SvJaeC57BL6Krastm4TyjKrasMap2k7tm11TwadMap2k7tm12TwadTrp53tm1TyjTrp53tm1TyjKrastm4TyjKrasMap2k7tm11TwadTrp53tm1TyjMap2k7tm12Twad
• mammary gland hyperplasia_Map2k7<tm1.1Twad>/Map2k7<tm1.2Twad>,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
  http://metadb.riken.jp/0000630I129P2OlaHsdC57BL6CD1DBAFVBNMap2k7tm11TwadMap2k7tm12TwadTgMMTVcre4Mam0TgMMTVErbb21Pv0TgMMTVErbb21PvMap2k7tm11TwadTgMMTVcre4MamMap2k7tm12Twad
• increased lung adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Map2k7<tm1.1Twad>/Map2k7<tm1.2Twad>
  http://metadb.riken.jp/0002027B6CgKrastm4TyjMap2k7tm11TwadMap2k7tm12TwadKrastm4TyjKrasMap2k7tm11TwadMap2k7tm12TwadKrasKrastm4TyjMap2k7tm11TwadMap2k7tm12Twad
• increased mammary gland tumor incidence_Map2k7<tm1.1Twad>/Map2k7<tm1.2Twad>,Tg(MMTV-cre)4Mam/0,Tg(MMTV-Erbb2)1Pv/0
  http://metadb.riken.jp/0010299I129P2OlaHsdC57BL6CD1DBAFVBNMap2k7tm11TwadMap2k7tm12TwadTgMMTVcre4Mam0TgMMTVErbb21Pv0TgMMTVErbb21PvMap2k7tm11TwadTgMMTVcre4MamMap2k7tm12Twad
• no abnormal phenotype detected_Map2k7<tm1.1Twad>/Map2k7<tm1.1Twad>
  http://metadb.riken.jp/0002169B6CgMap2k7tm11TwadMap2k7tm11TwadMap2k7tm11TwadMap2k7tm11Twad