increased lung tumor incidence_Col1a1<tm5(CAG-FGFR2_iIIIb*W290C)Kkw>/Col1a1<+>,Trp53<tm1Brn>/Trp53<tm1Brn>

http://metadb.riken.jp/0008014I129P2OlaHsd129S4SvJaeBALBcC57BL6Col1a1tm5CAGFGFR2iIIIbW290CKkwCol1a1Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnCol1a1Col1a1tm5CAGFGFR2iIIIbW290CKkw

increased lung tumor incidence_Col1a1<tm5(CAG-FGFR2_iIIIb*W290C)Kkw>/Col1a1<+>,Trp53<tm1Brn>/Trp53<tm1Brn>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• collagen, type I, alpha 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88467
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Col1a1<tm5(CAG-FGFR2_iIIIb*W290C)Kkw>/Col1a1<+>,Trp53<tm1Brn>/Trp53<tm1Brn>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Brn>|Col1a1<+>|Col1a1<tm5(CAG-FGFR2_iIIIb*W290C)Kkw>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased lung tumor incidence
  http://purl.obolibrary.org/obo/MP_0008014

文献

http://purl.org/net/cito/citesAsAuthority

• Jeremy H. Tchaicha, et.al., Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC., Cancer research, 2014, 74
  http://rdf.ncbi.nlm.nih.gov/pubmed/25035393