Jeremy H. Tchaicha, et.al., Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC., Cancer research, 2014, 74

http://rdf.ncbi.nlm.nih.gov/pubmed/25035393

Jeremy H. Tchaicha, et.al., Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC., Cancer research, 2014, 74

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm5(CAG-FGFR2_iIIIb*W290C)Kkw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5661327
• Col1a1<tm4(CAG-FGFR2_iIIIb*K660N)Kkw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5661319

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• premature death_Col1a1<tm4(CAG-FGFR2_iIIIb*K660N)Kkw>/Col1a1<+>,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0002083I129P2OlaHsd129S4SvJaeBALBcC57BL6Col1a1tm4CAGFGFR2iIIIbK660NKkwCol1a1Trp53tm1BrnTrp53tm1BrnCol1a1Trp53tm1BrnCol1a1tm4CAGFGFR2iIIIbK660NKkw
• increased lung tumor incidence_Col1a1<tm5(CAG-FGFR2_iIIIb*W290C)Kkw>/Col1a1<+>,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0008014I129P2OlaHsd129S4SvJaeBALBcC57BL6Col1a1tm5CAGFGFR2iIIIbW290CKkwCol1a1Trp53tm1BrnTrp53tm1BrnTrp53tm1BrnCol1a1Col1a1tm5CAGFGFR2iIIIbW290CKkw
• increased lung adenocarcinoma incidence_Col1a1<tm4(CAG-FGFR2_iIIIb*K660N)Kkw>/Col1a1<+>,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0002027I129P2OlaHsd129S4SvJaeBALBcC57BL6Col1a1tm4CAGFGFR2iIIIbK660NKkwCol1a1Trp53tm1BrnTrp53tm1BrnCol1a1Trp53tm1BrnCol1a1tm4CAGFGFR2iIIIbK660NKkw
• increased lung tumor incidence_Col1a1<tm4(CAG-FGFR2_iIIIb*K660N)Kkw>/Col1a1<+>,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0008014I129P2OlaHsd129S4SvJaeBALBcC57BL6Col1a1tm4CAGFGFR2iIIIbK660NKkwCol1a1Trp53tm1BrnTrp53tm1BrnCol1a1Trp53tm1BrnCol1a1tm4CAGFGFR2iIIIbK660NKkw
• increased lung tumor incidence_Col1a1<tm4(CAG-FGFR2_iIIIb*K660N)Kkw>/Col1a1<+>
  http://metadb.riken.jp/0008014I129S4SvJaeBALBcC57BL6Col1a1tm4CAGFGFR2iIIIbK660NKkwCol1a1Col1a1Col1a1tm4CAGFGFR2iIIIbK660NKkw
• weight loss_Col1a1<tm4(CAG-FGFR2_iIIIb*K660N)Kkw>/Col1a1<+>,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0001263I129P2OlaHsd129S4SvJaeBALBcC57BL6Col1a1tm4CAGFGFR2iIIIbK660NKkwCol1a1Trp53tm1BrnTrp53tm1BrnCol1a1Trp53tm1BrnCol1a1tm4CAGFGFR2iIIIbK660NKkw
• respiratory distress_Col1a1<tm4(CAG-FGFR2_iIIIb*K660N)Kkw>/Col1a1<+>,Trp53<tm1Brn>/Trp53<tm1Brn>
  http://metadb.riken.jp/0001954I129P2OlaHsd129S4SvJaeBALBcC57BL6Col1a1tm4CAGFGFR2iIIIbK660NKkwCol1a1Trp53tm1BrnTrp53tm1BrnCol1a1Trp53tm1BrnCol1a1tm4CAGFGFR2iIIIbK660NKkw

class

http://purl.org/net/cito/citesAsAuthority

• Col1a1<tm5(CAG-FGFR2_iIIIb*W290C)Kkw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5661327
• Col1a1<tm4(CAG-FGFR2_iIIIb*K660N)Kkw>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5661319