increased lung tumor incidence_Kras<tm4Tyj>/Kras<+>,Pik3r1<tm1Lca>/Pik3r1<+>,Pik3r2<tm1Lca>/Pik3r2<tm1Lca>

http://metadb.riken.jp/0008014I129S4SvJae129S6SvEvTacKrastm4TyjKrasPik3r1tm1LcaPik3r1Pik3r2tm1LcaPik3r2tm1LcaPik3r1tm1LcaPik3r1Krastm4TyjKrasPik3r2tm1Lca

increased lung tumor incidence_Kras<tm4Tyj>/Kras<+>,Pik3r1<tm1Lca>/Pik3r1<+>,Pik3r2<tm1Lca>/Pik3r2<tm1Lca>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• phosphoinositide-3-kinase regulatory subunit 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:1098772
• phosphoinositide-3-kinase regulatory subunit 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97583

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Pik3r1<tm1Lca>/Pik3r1<+>,Pik3r2<tm1Lca>/Pik3r2<tm1Lca>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pik3r1<tm1Lca>|Pik3r1<+>|Kras<tm4Tyj>|Kras<+>|Pik3r2<tm1Lca>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * 129S6/SvEvTac

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased lung tumor incidence
  http://purl.obolibrary.org/obo/MP_0008014

文献

http://purl.org/net/cito/citesAsAuthority

• Jeffrey A. Engelman, et.al., Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers., Nature medicine, 2008, 14
  http://rdf.ncbi.nlm.nih.gov/pubmed/19029981